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Effect of Kamihyungbangjihwang-tang on Immediate-type Allergic Reaction  

Kim Kwang Sik (College of Pharmacy, Woosuk University)
Lee Dong Hee (College of Pharmacy, Woosuk University)
Ko Dae Woong (College of Pharmacy, Woosuk University)
Song Jung Mo (College of Oriental Medicine. Woasuk University)
Eun Jae Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1270-1275 More about this Journal
Abstract
The purpose of this research was to investigate the effects of Kamihyungbangjihwang-tang (KHT) on immediate-type allergic reaction. KHT was composed of hyungbangjihwangtang (HJT) and Rubus coreanus Miquel (RC) and Aspalathus linear is (AL). KHT and HJT (500 mg/kg) inhibited the systemic anaphylaxis induced by compound 48/80 and inhibited the passive cutaneous anaphylaxis (PCA) induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin (HSA) in vivo. In addition, KHT, HJT, RC and AL inhibited the release of histamine and increased the release of cAMP from rat peritoneal mast cells. The anti-allergic action of KHT was more potent than those of HJT. These results indicate that KHT may be useful for the prevention and treatment of type I allergy related disease via inhibition of histamine release from mast cells.
Keywords
Kamihyungbangjihwang-tang(加味荊防地黃湯); Rubus coreanus Miquel; Aspalathus Iinearis; mast cell, histamine; cAMP;
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