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Study on the Effects of Fructus Schizandrae on the Cerebral Blood Flow and Blood Pressure  

Whang Il Taek (Department of Pharmacology, College of Oriental Medicine)
Kim Kyung Soo (Department of Pharmacology, College of Oriental Medicine)
Park Jin Young (Department of Pharmacology, College of Oriental Medicine)
Kim Chun Soo (Professional Graduate School of Oriental Medicine. Wonkwang University)
Song Jung Suk (Professional Graduate School of Oriental Medicine. Wonkwang University)
Han Jong Hyun (Professional Graduate School of Oriental Medicine. Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1224-1230 More about this Journal
Abstract
The purpose of this present study is to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats. following the intravenous injection of drug. The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure tranducer(Grass, USA) in anesthetized adult Sprague-Dawley rats about for 2h to 2h and a half through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as following. 1. Fructus Schizandrae increased the changes of rCBF in rats, significantly. 2. The rCBF of Fructus Schizandrae did not change by pretreated propranolol. 3. The rCBF of Fructus Schizandrae did not change by pretreated atropine. 4. The rCBF of Fructus Schizandrae did not change by pretreated I-NNA. 5. The rCBF of Fructus Schizandrae was decreased by pretreated methylene blue. 6. The rCBF of Fructus Schizandrae did not change by pretreated indomethacin. 7. Fructus Schizandrae decreased the changes of blood pressure significantly. 8. The BP of Fructus Schizandrae did not change by pretreated propranolol. 9. The BP of Fructus Schizandrae did not change by pretreated atropine. 10. The BP of Fructus Schizandrae did nol change by pretreated I-NNA. 11. The BP of Fructus Schizandrae was decreased by pretreated methylene blue. 12. The BP of Fructus Schizandrae did not change by pretreated indomethacin. These results indicate that Fructus Schizandrae can increase the rCBF and decrease the BP, that related to guanylyl cyclase activity.
Keywords
rCBF(regional cerebral blood flow); BP(blood pressure); Fructus Schizandrae;
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