[KSCI] Korea Science Citation Index Service

Effect of Sojagangqi-tang on the Immunomodulatory Action 소자강기탕의 면역조절효과

Shin Hyun Jong (Department of Pathology. College of Oriental Medicine. Woosuk University)
Jeong Sang Hun (Department of Pathology. College of Oriental Medicine. Woosuk University)
Jeong Han Sol (Department of Pathology. College of Oriental Medicine. Woosuk University)
Lee Kwang Gyu (Department of Pathology. College of Oriental Medicine. Woosuk University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1182-1187 More about this Journal

Abstract

The purpose of this research was to investigate the effect of Sojagangqi-tang(SJGQT) on the immune cell activity. The addition of SJGQT enhanced the proliferation of cultured-mice splenocytes and thymocytes. Administration of SJGQT(250 mg/kg) accelerated the subpopulation of splenic T lymphocytes especially CD/sup 4+/-TH cells in BALB/c mice. But high concentration(500 mg/kg) of SJGQT decreased the splenic T, B lymphocytes and thymic Tc (CD/sup 8+/) lymphocytes. Oral administration of SJGQT(250 mg/kg) significantly enhanced the production of IFN-γ and IL-4 in mice serum. And also, the addition of SJGQT(100 ㎍/ml) inhibited the proliferation of cultured-Jurkat leukemia cells in vitro. These results suggest that SJGQT have a cellular immuno-modulatory effect and anti-cancer property action

Keywords

Sojagangqi-tang(蘇子降氣湯); IFN-γ; IL-4; immune-modulatory;

Citations & Related Records

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