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Effect of Unripened fruits and Ripened fruits of Rubus coreanus Miquel on Murine Peritoneal Macrophages  

Lee Taek Yul (College of Pharmacy, Woosuk University)
Kim Dae Keun (College of Pharmacy, Woosuk University)
So June No (College of Science and Technology, Woosuk University)
Kwon Jin (Department of Health Administration, Kunjang College)
Song Jung Mo (College of Oriental Medicine, Woosuk University)
Eun Jae Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 991-995 More about this Journal
Abstract
The purpose of this research was to investigate the effects of unripened fruits and ripened fruits of Rubus coreanus Miquel on murine peritoneal macrophages. The 70% ethyl alcohol extracts (20 or 100 mg/kg) of unripened fruits (RCE-I) and of ripened fruits (RCE-II) were administered p.o. once a day for 7 days to mice. RCE-I and RCE-II decreased the phagocytic activity of murine peritoneal macrophages and the production of nitric oxide. Also, RCE-I and RCE-II increased the production of tumor necrosis factor- a from peritoneal macrophages. In general, the immuno-suppressive action of RCE-I on macrophages was more potent than those of RCE-II. These results suggest that the fruits of Rubus coreanus Miquel regulates the non-specific immune response via decrease of phagocytic activity and increase of production of tumor necrosis factor- a from murine peritoneal macrophages.
Keywords
Rubus coreanus Miquel; peritoneal macrophage; phagocytosis; tumor necrosis factor-α;
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