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A Study on Cytokine Modulating Effect of Three Origins of Phellinus Linteus  

Kim Jin Soo (Oriental medical College, Daejeon University)
Kim Jung Hyo (Nursing college, Chosun University)
Lee Hyo Jeong (Department of Sports science, Kyunghee University)
Khil Jae Ho (Department of Sports Science, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Kyunghee University)
Kim Dong Hee (Oriental Medical College, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 898-904 More about this Journal
Abstract
Pellinus linteus has been used for the prevention of cancer traditionally. There are three origins of Pellinus linteus, Korea, China and Cambodia. However, their immunological activities were not evlauated comparatively. Thus, this study was done to evaluate immunomodulatory effects of Phellinus linteus(PL) from Korea, china and cambodia, We confirmed PL showed two major protein bands, 50 kDa and 80 kDa by protein analysis. These PL effectively upregulated the expressions of IL-2 at 10 ug/ml and GM-CSF, IL-4, IL-10, IL-12(p35), IL-12(p40), IL-18, IFN-r in all concentrations. However, Korea-PL upregulated the expression of IL-12 more effectively than the other PLs. It intended to increase NO with no significance. Those results indicate Phellinus linteus had cytokine modulating effect
Keywords
Pellinus linteus; Korea-Pl; China-Pl; Cambodia-Pl; cytokine; three origins; IL-12;
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