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Aqueous Extract of Ma huang Decreases Neuropeptide Y Expression in the Hypothalamus of Rats

Shin Mal Soon (Department of Physiology, College of Medicine, Kyung Hee University)
Shin Min Chul (Department of Physiology, College of Medicine, Kyung Hee University)
Jang Mi Hyean (Department of Physiology, College of Medicine, Kyung Hee University)
Chang Hyun Kyung (Department of Physiology, College of Medicine, Kyung Hee University)
Kim Chang Ju (Department of Physiology, College of Medicine, Kyung Hee University)
Kim Jeong Sean (Department of Oriental Medical Food & Nutrition, Semyung University)
Kim Ee Hwa (Department of Meridian & Acupoint, College of Oriental Medicine, Semyung University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 1116-1119 More about this Journal

Abstract

Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et CA, is one of the well known medicinal herbs, and has been used for the diaphoretic, antiasthmatic, and diuretic actions. Ma huang is an ephedrine type alkaloid used for the weight loss and energy expenditure. Medications based on the Ma huang have been found to be effective in the treatment of obesity. Neuropeptide Y (NPY), a 36-amino-acid peptide and concentrated in the hypothalamus, stimulates feeding desire and decrease energy expenditure. In the present study, the effect of Ma huang on the expression of NPY in the rat hypothalamus was investigated using immunohistochemistry. The present results demonstrated that Ma huang treatment suppressed weight gain and NPY expression in the hypothalamus depending upon the dosage used. Based on the results, it can be suggested that Ma huang treatment is effective in curbing the desire for food via modulation of NPY expression under the normal conditions.

Keywords

Ma huang; neuropeptide Y; hypothalamus; immunohistochemistry; weight loss;

Citations & Related Records

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