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Effects of Tongryeong-san and Constituents Extract in Cultured Rat Myocardial Cells  

Seong Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Su (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kang Gil Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Gyu (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 1031-1036 More about this Journal
Abstract
To certify the protective effect of herbal medicine against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using TBARS assay and Beating rate in the presence of Tongryeong-san(TRS) extracts or single constituents of this prescription. Myocardial toxicity was evaluated in neonatal rat myocardiocytes in cultures. In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a increase in lipid peroxidation and decreases in beating rate in cultured myocardial cells. In the effect of TRS extract, it showed the prevention from the XO/HX-induced cardiotoxicity by the increases of beating rate as well as the decrease of lipid peroxidation, In the protective effect of Faeces Trogopterori(FT), Pollen Typhae(PT), Caulis Akebiae(CA) and Radix Paeoniae Rubra(PRR), all the extracts were significantly effective in the protection of XO/HX-induced cardiotoxocity in cultured myocardial cells by the increase of beating rate as well as th decrease of lipid peroxidation. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rat, and it suggests that TRS, FT, PT, CA and PRR extracts are positively effective in the blocking in XO/HX-induced cardiotoxicity.
Keywords
Tongryeong-san(通靈散); Faeces Trogopterori; Pollen Typhae; Caulis Akebiae; Paeoniae Rubra; xanthine oxidase/hypoxanthine; Myocardial cell; CardiotoKicity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 失笑散 전탕액이 XO/HX에 의해 손상된 배양 심근세포 박동수에 미치는 영향 /
[ 한동훈;권강범;황인진;김우경;김희찬;오광수;이호승;류도곤 ] / 대한동의생리병리학회지
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