Apoptotic Cell Death of Human Lung Carcinoma A549 Cells by an Aqueous Extract from the Roots of Platycodon grandiflorum
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Lee Sung Yeoul
(Department of Internal medicine, College, of Oriental Medicine Dongeui University)
Kim Won Ill (Department of Internal medicine, College, of Oriental Medicine Dongeui University) Park Dong Il (Department of Internal medicine, College, of Oriental Medicine Dongeui University) |
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Research technics for the cell cycle study
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DOI ScienceOn |
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Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.
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Apoptotic activity of novel bile acid derivatives in human leukemic T cells through the activation of caspases.
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Regulation of cyclin D1 by calpain protease.
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DOI ScienceOn |
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Cleavage of poly ADP-ribose polymerase by a proteinase with properties like ICE.
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DOI ScienceOn |
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Yama/CPP32, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
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DOI ScienceOn |
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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
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XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human overian epithelial cancer cells.
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Is COX-2 inhibition a panacea for cancer prevention?
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DOI ScienceOn |
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Cyclooxygenase-2:a novel target for cancer chemotherapy?
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DOI ScienceOn |
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Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo.
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Therapeutic potential of inhibition of the NF-κ B pathway in the treatment of inflammation and cancer.
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DOI ScienceOn |
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Pharmacological activities of crude platycodin.
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Studies on antiinflammatory effect of Japanese oriental medicines (kampo medicines) used to treat inflammatory diseases.
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DOI |
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Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters.
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DOI ScienceOn |
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Immune pharmacological studies on platicodi radix.I.Effect on the phagocytosis in the mouse.
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Pharmaceutical substances of Platycodon grandiflorum(jacquin) A.
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A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis.
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DOI ScienceOn |
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Pharmacological studies on Platycodon grandiflorum A.
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DOI |
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Studies on immunomodulation function of components separated from Platycodi radix.
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Cell adhesion molecules in the development and progression of malignant melanoma.
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Antitumor and immunonodulatory activities of the Platycodon grandiflorum cultivated for more than 20 years.
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Effect of Platycodon grandiflorum DC extract on the growth of cancer cell lines
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Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice.
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Aqueous extract isolated from Platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis tactor-α from murine macrophages.
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Apoptosis.The role of the endonuclease.
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Multiple pathways to apoptosis.
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Necrosis and apoptosis in acute renal failure.
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Premature p34cdc2 activation required for apoptosis.
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Apoptosis and the cell cycle.
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
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The Bcl-2 protein family.
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DOI ScienceOn |
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Cyclooxygenase-2:a therapeutic target.
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DOI ScienceOn |
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COX-2 inhibition and prevention of cancer.
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DOI |
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The aqueous extract from Platycodi radix attenuates lipopolysaccharide-induced NF-κ B activation in RAW 264.7 cell and acute lung injury in rats
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37 |
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals:down-regulation of COX-2 and iNOS through suppression of NF-κ B activation.
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DOI ScienceOn |
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Cox-2,iNOS and -53 as play-makers of tumor angiogenesis.
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Nonsteroidal anti-inflammatory drugs as anticancer agents:mechanistic,pharmacologic, and clinical issues.
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Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells.
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41 |
Specific proteolytic cleavage of poly(ADP-ribose) polymerase:an early marker of chemotherapy-induced apoptosis.
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E0cadherin-catenin cell-cell adhesion complex and human cancer.
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DOI ScienceOn |
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The role of the E-cadherin/catenin complex in gastrointestinal cancer.
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Apoptosis-associated cleavage of ß-catenin in human colon cancer and rat hepatoma cells.
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DOI ScienceOn |
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Apoptosis-induced cleavage of ß-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential.
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Anti-apoptotic versus pro-apoptotic signal transduction:checkpoints and stop signs along the road to death.
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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.
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Studies of inositol phospholipid-specific phospholipase C.
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Overexpression of phospholipase C-1 in rat 3Y1 fibroblast cells leads to malignant transformation.
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Src homology domains of phospholipase C gamma1 inhibit nerve growth factor-induced differentiation of PC12 cells.
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Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.
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Prevention of phosphatidaylinositol 3-kinase-Akt survival signaling pathway during topotecan-induced apoptosis.
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Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.
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The nuclear phosphoinositide 3-kinase/AKT pathway:a new second messenger system.
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Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.
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Akt regulates cell survival and apoptosis at a postmitochondrial level.
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Augmentation of macrophage function by and aqueous extract isolated from Platycodon grandiflorum.
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Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells.
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Immune pharmacological studies on platicodi radix (II). Antitumor activity of inulin from platicodi radix.
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Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
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DOI ScienceOn |
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Apoptosis by death factor.
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