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Kagam-bojungikgitang Inhibits LPS-induced Inflammatory Mediators in RAW 264.7 Macrophages  

Jang Seon Il (Immunopia Research Laboratory of Molecular and Cellular Immunology)
Kim Hyung Jin (Immunopia Research Laboratory of Molecular and Cellular Immunology)
Kim Young Jun (Immunopia Research Laboratory of Molecular and Cellular Immunology)
Pae Hyun Ock (Medical Resources Research Center, Wonkwang University)
Chung Hun Taeg (Immunopia Research Laboratory of Molecular and Cellular Immunology)
Jeong Ok Sam (College of Pharmacy, Wonkwang University)
Kim Youn Chul (Immunopia Research Laboratory of Molecular and Cellular Immunology)
Yun Yong Gab (Department of Oriental Medical Prescription, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 804-809 More about this Journal
Abstract
Kagam-bojungikgitang is the water extracts prepared from Ginseng Radix, Astragali Radix. Angelicae gigantis Radix, Astractylodis Rhizoma alba, Aurantii nobilis Pericarpium, Glycyrrhizae Radix, Artemisiae iwayomogii Herba, and Scutellariae Radix. This is a modified prescription of Bojungikgitang, which has been used for the treatment of indigestion, and immunological disease in oriental countries. In this study, the effects of Kagam-bojungikgitang and Bojungikgitang on the production of prostaglandin E₂ (PGE₂) and the expression of cyclooxygenase-2 (COX-2) were examined using RAW 264.7 macrophages activated with lipopolysaccharide (LPS). Both prescriptions dose-dependently reduced the release of PGE2 and expression of COX-2 caused by stimulation of LPS without cytotoxic effect. Kagam-bojungikgitang's inhibitory effects were better than Bojungikgitang in PGE2 production and COX-2 expression. Moreover, Kagam-bojungikgitang also attenuated markedly the production of tumor necrosis factor (TNF)-α, and IL-6 than Bojungikgitang in LPS-stimulated RAW 264.7 macrophages. These results suggest that Kagam-bojungikgitang decreases PGE2 and pro-inflammatory cytokine production in macrophages and these properties may contribute to the anti-inflammatory activity of Kagam-bojungikgitang.
Keywords
Kagam-bojungikgitang; prostaglandin E₂; pro-inflammatory cytokine; cyclooxygenase-2;
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