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Effect of Yanggyuksanhwa-tang on Pyramidal Neuron and HSP72 Expression in Ischemic Damaged Hippocampus of Aged BCAD Rats  

Park Eun Kyung (Department of Anatomy, College of Oriental Medicine, Kyunghee University)
Shin Jung Won (Department of Neuroscience, Graduate School of East-West Medical Science, Kyunghee University)
Sohn Young Joo (Department of Neuroscience, Graduate School of East-West Medical Science, Kyunghee University)
Jung Hyuk Sang (Department of Anatomy, College of Oriental Medicine, Kyunghee University)
Won Ran (Department of Neuroscience, Graduate School of East-West Medical Science, Kyunghee University)
Sohn Nak Won (Department of Neuroscience, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 791-797 More about this Journal
Abstract
This study investigated the effect of Yanggyuksanhwa-tang on cerebral ischemia of the rats. Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries (BCAO) under the hypotension. Yanggyuksanhwa-tang was administered twice orally. Then changes of pyramidal neurons and heat shock protein 72 (HSP72) expressions in ischemic damaged hippocampus were of observed. The BCAO in aged rats led significant decrease of pyramidal neurons in CA1 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the reduction of pyramidal neurons in CA1 hippocampus following BCAO ischemia. The BCAO in aged rats led significant increase of HSP72 expression in CA1 and mild in CA3 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of HSP72 expression in CA1 hippocampus following BCAO ischemia. The extent of HSP72 expression in CA2 and DG of hippocampus was not different between the sham operated group, the BCAO ischemia control group, and the group of Yanggyuksanhwa-tang administration after BCAO ischemia. The treatment of Yanggyuksanhwa-tang significantly attenuated the increase of normalized optical density depending on HSP72 expression in CA1 hippocampus following BCAO ischemia.
Keywords
Aging; Ischemia; Heat shock protein; Yanggyuksanhwa-tang; Rat;
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