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Prospective Evaluation of the G-protein $\beta$3 Subunit (GNB3) Gene 825T Polymorphism is Associated With Cerebral Infarction in Korean Population  

Choi Min Hee (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Lee Jin Woo (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Lee Kyung Jin (Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
Lee Hyo Jung (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Rho Sam Woong (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Choi Hyun (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Cho Ki Ho (Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
Hong Moo Chang (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Shin Min Kyu (Department of Physiology, College of Oriental Medicine, Kyunghee University)
Kim Young Suk (Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
Bae Hyun Su (Department of Physiology, College of Oriental Medicine, Kyunghee University, Purimed R&D Institute)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 719-727 More about this Journal
Abstract
Background and purpose: Hypertension and obesity has been implicated in the most important risk factors for stroke. The original finding that the G-protein beta3 subunit (GNB3) C825T allele associates with essential hypertension and obesity has been confirmed in several different populations. Hence, our objective was to determine whether the GNB3 C825T polymorphism predicts interindividual variation in stroke. Method: We recruited 361 stroke patients (cerebral infarction, n=278; intracerebral hemorrhage (ICH), n=83) and 199 healthy control subjects. Subjects were genotyped for GNB3 C825T mutation and findings were investigated for association with stroke. Result: The GNB3 T/T type was significantly associated with cerebral infarction prevalence (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015). While, ICH was not found to be significantly associated with GNB3 T/T type (OR, 1.63; 95% ICH, 0.74-3.56; p=0.219). Similarly, no significant association was determined between GNB T/C type, and cerebral infarction (OR, 1.09; 95% Cl, 0.68-1.74; p=0.716), and ICH (OR, 1.14; 95% Cl, 0.59-2.21; p=0.697). Conclusion: In clinical characteristics, this study shows no differences among GNB3 genotypes, that are BMI, WH ratio. hypertension rate, and ischemic heart disease rate, total lipid level, triglycerides level, total cholesterol level, HDL cholesterol level, prothrombine time, with the exception of LDL cholesterol concentrations. However, our subjects showed an inverse relationship between LDL cholesterol level and the risk of cerebral infarction. We have shown that the GNB3 T/T genotype is strongly associated with cerebral infarction. (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015).
Keywords
GNB3; polymorphism; Stroke; Cerebral Infarction; Intracerebral hemorrhage;
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