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Effects of Sophorae Radix Extract in Pulmonary Vascular Endothelial Cells Damaged by XO/HX  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Lee Ho Seung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Su (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Gyu (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 549-552 More about this Journal
Abstract
To investigate the protective effect of Sophorae Radix (SR) on the damage by pulmonary vascular endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen tree radical, Neutral Red (NR) and c-fos immunopositive cell assay were used. The results were obtained as follows ; The viability of vascular endothelial cells treated with XO/HX was decreased. And c-fos immunopositive cells represented a maximal increase in group treated with XO/HX for 2 hour in pulmonary vasvular endothelial cells. But pretreated groups with SR extracts were not inhibited the increase of c-fos immunopositive cells by XO/HX in a dose-dependent manner. These results show that XO/HX elicits toxic effects in cultured pulmonary vascular endothelial cells, and suggest that SR extract is very effective in the prevention of XO/HX-induced increase of c-fos immunopositive cells.
Keywords
Sophorae Radix(苦蔘); Neutral Red; c-fos immunopositive cells; xanthine oxidase/hypoxanthine;
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Times Cited By KSCI : 1  (Citation Analysis)
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