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Antioxidant Activities of Glycyrrhizin and its Effect on Renal Expression of Na,K-ATPase in Gentamicin-induced Acute Renal Failure Rats  

Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee An Sook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Yun Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Yin Ming Hao (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Yeum Kee Bok (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Noh Suk Yun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 542-548 More about this Journal
Abstract
The present study was aimed to investigate whether glycyrrhizin, which is the major component of Glycyrrhiza uralensis, has an antioxidant effect and regulatory effect on Na,K-ATPase in gentamicin-induced acute renal failure (ARF) rats . It is well known that reactive oxygen species (ROS), such as superoxide anion and hydroxyl radical, are main pathophysiological factor in gentamicin-induced ARF. Glycyrrhizin showed potent in vitro antioxidant activity, especially superoxide scavenging activity, in a dose-dependent manner. Plasma lipid peroxide level was restored to normal level by oral administration of glycyrrhizin (200 mg/kg) in the gentamicin-induced ARF rats. The expression of Na,K-ATPase α1 subunit was restored in the gentamicin-induced ARF rats by administration of glycyrrhizin, whereas β1 subunit was not restored. The renal functional parameters including urine volume, cleatinine clearance, urine osmolality, solute-free water reabroption were also partially restored in gentamicin-ARF rats by administration of glycyrrhizin. Taken together, the amelioration of renal functions and the expression of sodium pump by administration of glycyrrhizin in the gentamicin-induced ARF was appear to be mediated by the scavenging of ROS.
Keywords
glycyrrhizin; Na,K-ATPase; gentamicin-ARF rats; reactive oxygen species;
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