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Particle Size Analysis of Lead Aerosol with the use of 2730ppm Lead Nebulizing Solution for Inhalation Toxicology Study  

Jeung Jae Yeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang Sung Ho (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim Sam Tae (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Eun Kyoung (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Song Young Sun (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Ki Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 518-524 More about this Journal
Abstract
Ultrasonic nebulizer with the application of new engineering methodology and the design of electronic circuit was made for lead inhalation toxicology study and 2730ppm lead nebulizing solution was used to generate lead aerosol. After modification of source and inlet temperatures, the results of particle size analysis for lead aerosol were as following. The highest particle counting for source temperature 20℃ was 39933.66 in inlet temperature 100℃ and particle diameter 0.75tLm. The highest particle counting for source temperature 50℃ was 39992.71 in inlet temperature 250℃ and particle diameter 0.75μm. The highest particle counting for source temperature 70℃ was 37569.55 in inlet temperature 50℃ and particle diameter 0.75μm. The ranges of geometric mean diameter(GMD) were 0.754-0.784μm for source temperature 2℃, 0.758-0.852μm for source temperature 50℃, and 0.869-1.060μm for source temperature 70℃. The smallest GMD was 0.754μm in source temperature 20℃ and inlet temperature 20℃, and the largest GMD was 1.060μm in source temperature 70℃ and inlet temperature 250℃. The ranges of geometric standard deviation(GSD) were 1.730-1.782 for source temperature 20℃, 1.734-1.894 for source temperature 50℃, and 1.921-2.148 for source temperature 70℃. The lowest GSD was 1.730 in source temperature 20℃ and inlet temperature 20℃, and the highest GSD was 2.148 in source temperature 70℃ and inlet temperature 250℃. Lead aerosol generated in this study was polydisperse. The ranges of mass median diameter(MMD) were 1.856-2.133μm for source temperature 20℃, 1.877-2.894μm for source temperature 50℃, and 3.120-6.109μm for source temperature 70℃. The smallest MMD was 1.856μm in source temperature 20℃ and inlet temperature 20℃, and the largest MMD was 6.109μm in source temperature 70℃ and inlet temperature 250℃. Slight increases for GMD, GSD, and MMD values were observed with same source temperature and increase of inlet temperature. MMD for inhalation toxicology testing in EPA guidance is less than 4μm. In this study, source temperature 20℃ and 50℃ with inlet temperature from 20℃ to 250℃ were conformed to the EPA guidance, but inlet temperature 20℃ and 50℃ for source temperature 70℃ were conformed EPA guidance. MMD for inhalation toxicology testing in OECD and EU is less than 3μm. In this study, source temperature 20℃ and 50℃ with inlet temperature from 20℃ to 250℃ were conformed to the EPA guidance, but none for source temperature 70℃.
Keywords
Inhalation; ultrasonic nebulizer; nebulizing solution; lead aerosol; particle size; particle counting; geometric mean diameter; geometric standard deviation; mass median diameter; polydisperse aerosol;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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