[KSCI] Korea Science Citation Index Service

Effects of Mangeum-tang and Gamimangeum-tang on the Cultured Spinal Dorsal Root Ganglion Cells

Choi Gyu Seon (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Yun Sang Hak (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Yeom Seung Ryong (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Lee Su kyung (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Shin Byung Cheul (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Kwon Young Dal (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
Song Yung Sun (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 503-509 More about this Journal

Abstract

The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine (XO/HX) and the effects of herbal extracts such as Mangeum-tang (萬金湯: MGT) and Gamimangeum-tang (加味萬金湯: GMGT) on the treatment of the toxic effects. The results of these experiments were XO/HX, an oxygen radical-generating system, decreased the survival rates of the cultured cells on XTT assay, the amount of DNA syntheses, and the amount of neurofilaments, and increased c-fos positive cells, MGT and GMGT have the efficacy of increasing the survival rates of the cultured cells by increasing the amount of neurofilaments and DNA synthesis and decreasing the c-fos positive cells damaged by XO/HX, From the above results, it is suggested that MGT and GMGT have marked efficacy as a treatment for the damages caused by the XO/HX-mediated oxidative stress. And MGT and GMGT are thought to have certain pharmacological effects.

Keywords

Mangeum-tang(萬金湯); Gamimangeum-tang(加味萬金湯); Xanthine Oxidase (XO); Hypoxanthine (HX); XTT; Neurofilament; DNA synthesis; c-fos;

Citations & Related Records

Reference

1	Interaction of cadmium with rat testicular interstitial cell nuclei : Alterations induced by zinc pretreatment and cadmium binding proteins. / [ Koizumi, T.;Waalkes, M.P. ] / Toxicoa In Vitro DOI
2	東醫寶鑑 에 나타난 麻木不仁에 對한 小考 / [ 조한숙;송태원;김신석 ] / 한방재활의학회지
3	麻木에 關한 관한 文獻的考察. / [ 鄭錫熙;李鍾秀;金性洙;申鉉大 ] / 대한한의학회지
4	素問<TEX>$\cdot$</TEX>痿論에 對한 硏究 / [ 嚴祥燮 ] /
5	/ [ 孫思邈 ] / 千金要方
6	/ [ 陳自明 ] / 婦人良方大全
7	/ [ 陳師文 ] / 太平惠民和劑局方
8	十全大補湯加鹿茸이 마우스의 免疫反應에 미치는 影響 / [ 황충연 ] /
9	釣鉤藤煎湯液이 XO/HX에 의해 損傷된 培養脊髓感覺神經細胞에 미치는 影響 / [ 황홍연 ] /
10	釣鉤藤水鍼이 鎭痛, 抗痙攣 및 鎭靜作用에 미치는 影響 / [ 신명섭 ] /
11	白彊蠶이 血壓 및 局所腦血流量에 미치는 影響 / [ 황경택 ] /
12	白彊蠶煎湯液이 Hydrogen Peroxide에 의해 損傷된 培養脊髓運動神經細胞에 미치는 效果 / [ 이민주 ] /
13	Excitatory amino acid and free radical formation may cooperate in the genesis of ischemia-¬induced neuronal damage. / [ Pellegrini-Giampietro, D.E.;Cherici, G.;Alesiani, M.;Carrla, V.;Moroni, F. ] / J Neurosci DOI
14	Permeation and block of N-methyl- D-aspartic acid receptor channels by divalent cautions in mouse cultured central neurons. / [ Mayer, M.L.;Westbrook, G.L. ] / J Physiol DOI
15	Excitatory amino acids, free radicals and the pathogenesis of motor neurons disease. / [ Zeman, S.;Lioyd, C.;Meldrum, B.;Leigh, P.N. ] / Neuropathol Appl Neurobiol DOI
16	Mutation in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. / [ Rosen, D.;Siddique, T.;Patterson, D.;Figlewiex, D.;Sapp, P.;Hentati, A.;Deng, H.;Rahmani, Z.;Krizus, A. ] / Nature(London) DOI
17	A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and protective effect of alpa-tocopherol administration. / [ Yamamoto, M.;Scima, T.;Uozumi, T.;Yamada, K.;Kawasaki, T. ] / Stroke DOI ScienceOn
18	Effect of intermittent electrical stimulation of muscle atrophy in hindlimb suspended rats, / [ Park, B.R.;Kim, M.S.;Kim, S.G.;Kim, H.K.;Kim, S.S. ] / Proceeding of the 1st International FES Symposium
19	DNA damage / [ Friedberg, E.C. ] / DNA repair
20	In vitro cadmium-DNA interactions : Cooperativity of binding and competitive antagonism by calcium, magnesium and zinc. / [ Waalkes, M.P.;Poirier, L.A. ] / Toxicol Appl Pharmacol DOI
21	Oxygen radical-induced neurotoxicity in spinal cord beuron cultures. / [ Michikawa, M.;Lim, K.T.;McLamon, J.G.;Kim, S.U. ] / J Neurosci Res DOI
22	/ [ 한국한의학연구원 ] / 한의진단명과 진단요건의 표준화연구(III)
23	/ [ 김명호 ] / 기초 임상신경학
24	/ [ 피터두스 ] / 신경국소진단학
25	/ [ 全國韓醫科大學再活醫學科學敎室(編) ] / 東醫再活醫學科學
26	/ [ 危亦林 ] / 世醫得效方
27	/ [ 許浚 ] / 校正東醫寶鑑
28	/ [ 申載用 ] / 方藥合編解說
29	/ [ 尹用甲 ] / 東醫方劑와 處方鮮說
30	/ [ 辛民敎 ] / 臨床本草學
31	萬金湯 및 加味萬金湯이 高脂血症에 미치는 影響 / [ 徐雲敎 ] / 東國大學校韓醫學硏究所韓醫學論文集
32	萬金湯이 白鼠의 局所腦血流量 및 血壓에 미치는 影響 / [ 曺永敏 ] /
33	痺證에 對한 東西醫學的考察(原因, 症狀을 爲主로). / [ 金湘洙;高成奎;曺臺湖;金永錫;裵亨燮;李京燮 ] / 大韓韓方內科學會誌
34	/ [ 김승민;선우일남;이광수;최경규;최일생 ] / 임상신청 국소진단학
35	척수손상환자의 사회적응실태조사 / [ 최영래;김유철;조은수;최선미;김연희 ] / 대한재활의학회지
36	/ [ Cregory, D. Cramer;Susan, A. Darby. ] / Basic and clinical anatomy of the Spine, Spinal cord and ANS
37	素問<TEX>$\cdot$</TEX>痺論에 대한 硏究 / [ 張斗浩 ] /
38	Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation. / [ Pellegrini-Giampietro, D.E.;Cherici, G.;Alesiani, M.;Carrla, V.;Moroni, F. ] / J Neurochem DOI
39	痺證의 形證과 病域에 관한 文獻的考察 / [ 宋峰根 ] /

KSCI

Effects of Mangeum-tang and Gamimangeum-tang on the Cultured Spinal Dorsal Root Ganglion Cells 만금탕 및 가미만금탕이 배양 척수후근신경절 세포에 미치는 영향

Effects of Mangeum-tang and Gamimangeum-tang on the Cultured Spinal Dorsal Root Ganglion Cells