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Screening of Cytotoxicity and Antimicrobial Effects of Hexane Extracts from Cornis fructus  

Chun Hyun Ja (Division of Natural Science, Wonkwang University)
Choi Won Hyung (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Jeong Ho (Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Yang Hyun Ok (Department of Cosmetic, Wonkwang Health Science)
Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 476-480 More about this Journal
Abstract
Cornis fructus was extracted by successive extraction and then fractionated with hexane extract to get active fractions. This study was performed to determine the cytotoxic effect of hexane extract from Cornis fructus on NIH 3T3 fibroblasts and cancer cell lines using MTT assay. Hexane extract showed cytotoxic effect against A549, B16 melanoma and MDA-MB-231. Futher fractionation with hexane extract was performed to obtain effective fraction, fraction 3 showed the cytotoxic effect against A549 and MDA-MB-231. In antimicrobial test of each fraction of hexane extract, fraction 5 showed antimicrobial activities against P. putida and P. aeruginosa.
Keywords
Corni fructus; MTT assay; Cytotoxic effects; Antimicrobial activities;
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