Browse > Article

Mechanism of Jaeumgenby-tang adding Aurantii FructusㆍGastrodae Rhizoma on the Improvement and Changes of Cerebral Hemodynamics  

Im Gwang Mo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Park Choul Hoon (Department of Pathology, College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 416-422 More about this Journal
Abstract
Jaeumgenby-tang(JGT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo caused by deficiency of qi(氣) and blood(血). Effect of Aurantii Fructus(AF) take off the phlegm by promoting the circulation of qi, Gastrodae Rhizoma(GR) has effects treating for headache, vertigo by calming the liver and suppressing hyperactivity of the liver-yang(陽). And, We reported that JGT adding AFㆍGR extract(JGTAG) was significantly increased regional cerebral blood f1ow(rCBF) by dilating pial arterial diameter(PAD). Therefor we designed to investigate whether JGTAG is mediated by adrenergic β-receptor, cyclooxygenase or guanylate cyclase in normal rats. The changes of rCBF and mean arterial blood pressure(MABP) were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video microscope and width analyzer. The results were as follows in normal rats; Pretreatment with propranolol(1mg/kg, i.v.) was significantly inhibited JGTAG induced increase of rCBF, PAD and MABP, and pretreatment with indomethacin(1 mg/kg, i.v.) was significantly inhibited too. But pretreatment with methylene blue(10μg/kg, i.v.) were accelerated JGTAG induced increase of rCBF and MABP, but pretreatment with methylene blue was inhibited JGTAG induced increase of PAD. This results suggest that the mechanism of JGTAG is mediated by adrenergic β-receptor and cyclooxygenase.
Keywords
Jaeumgenby-tang adding Aurantii Fructus(滋陰建脾湯加枳殼)ㆍGastrodae Rhizoma; adrenergic β-receptor (propranolol); cyclooxygenase(indomethacin); guanylate cyclase(mrthylene blue); cerebral hemodynamics;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 痰飮에 관한 文獻的 考察 /
[ 李周姬;吳泰煥;鄭昇杞;李珩九 ] / 大田大學校 論文集
2 /
[ 神戶中醫學硏究會 ] / 漢方臨床入門
3 Nitric oxide macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells /
[ Stuehr, D.J.;Nathan, C.F. ] / J. Exp. Med.   DOI
4 Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep /
[ Iwamoto, J.;Yoshinaga, M.;Yang, S.P.;Krasney, E.;Krasney, J. ] / J. Appl Physiol
5 Comparison of the effects of NG-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats /
[ Wang, Q.;Pelligrino, D.A.;Paulson, O.B.;Lassen, N.A. ] / Brain Res.   DOI
6 Quantitative changes in regional cerebral blood flow of rats induced by alpha-and beta-adrenergic stimulants /
[ 58. Edvinsson, L.;Lacombe, P.;Owman, C.;Reynier-Rebuffel, A.M.;Seylaz, J. ] / Acta Physiol. Scand.   DOI
7 Effects of beta-adrenergic agents on the regional cerebral blood flow in cortex and thalamus of the cat /
[ Vlahov, V.;Bacracheva, N. ] / Arch Int Pharmacodyn Ther.
8 The cyclooxygenase inhibitors indomethacin and Rofecoxib reduced regional cerebral blood flow evoked by somatosensory stimulation in rats /
[ Bakalova, R.;Matsuura, T.;Kanno, I. ] / Exp. Biol. Med.   DOI
9 Role of inducible nitric oxide synthase and cyclooxygenase-2 endotoxin-induced cerebral hyperemia /
[ Okamoto, H.;Ito, 0.;Roman, R.J.;Hudetz, A.G. ] / Stroke   DOI   ScienceOn
10 Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation /
[ Shin, H.K.;Shin, Y.W.;Hong, K.W. ] / Am J. Physiol Heart Circ Physiol   DOI
11 Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries /
[ Yamamoto, S.;Nishizawa, S.;Yokoyama, T.;Ryu, H.;Uemura, K. ] / Brain Res.   DOI
12 SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors /
[ Iadecola, C.;Zhang, F.;Xu, X. ] / Am J. Physiol.
13 風의 病理的 意味糾明과 中風의 原因 및 治療에 대한 東西醫學的 比較 /
[ 金世吉 ] / 대한한의학회지
14 肝<TEX>$\cdot$</TEX>心<TEX>$\cdot$</TEX>賢兪에 艾灸施術과 Lasser光線鍼이 血壓과 腦血流量에 미치는 影響 /
[ 趙南根;金庚植 ] / 大韓針灸學會誌
15 眩暈의 病因病理에 관한 東西醫學的 考察 /
[ 宋孝貞 ] / 大韓韓醫學會誌
16 현훈의 침구치료에 관한 문헌적 고찰 /
[ 방규상 ] /
17 /
[ 김경환 ] / 이우주의 약리학 강의(제4판)
18 /
[ Snedecor, G.H.;Cocharn, W.C. ] / Statistical Methods
19 /
[ 康舜洙 ] / 바른 方劑學
20 /
[ 葉天士 ] / 臨正指南醫案
21 /
[ 朱丹溪 ] / 丹溪心法附餘
22 /
[ 李志庸 ] / 張景岳醫學全書
23 /
[ 劉河間 ] / 劉洞間三六書
24 /
[ 虞天民 ] / 醫學正博
25 /
[ 蔡陸仙 ] / 中醫醫藥匯海
26 Reactivity of rat pialarterioles and venules to adenosine and carbon dioxide , with detailed description of the closed cranial window technique in rats. /
[ Morii, S.;Ngai, A.C.;Winn, H.R. ] / J. Celeb Blood Flow Metab   DOI
27 Detailed description of a cranial window technique for acute and chronic experimentals /
[ Joseph E.;Lebasseur M.S.;Wei E.P.;Raper A.J.;Kontos H.A.;Patterson J.L. ] / Stroke   DOI   ScienceOn
28 /
[ 廉命吉 ] / 濟衆新篇
29 /
[ 전국한의과대학 병리학교실(編) ] / 한방병리학
30 石菖蒲가 白鼠의 腦軟膜動脈의 直徑에 미치는 機轉硏究 /
[ 李金洙;鄧鉉雨;康成溶 ] / 大韓本草學會誌
31 /
[ 上海中醫學院 ] / 中醫學基礎
32 滋陰健脾湯이 鎭諦, 補血效果에 관한 實驗的 硏究 /
[ 金俊顯;李京燮 ] / 大韓韓醫學會誌
33 /
[ 성호경 ] / 생리학(제6판)
34 Nitric oxide as a secretory product of mammalian cells /
[ Nathan, C. ] / FASEH J.
35 Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the Brain /
[ Carthwaite, J.Charles, S.L.;Chess-Williams, R. ] / Nature   DOI
36 Nitric oxide , A cytotoxic and activated macrophage effector molecule /
[ Hibbs, J.B.;Taintor, R.R.;Vavrin, Z.;Rachlin, E.M. ] / Boichem Biophysic Res Commum   DOI
37 Niric oxide sythesis inhibitioI\ induced leukocyte adhesion via superoxide and master cell /
[ Kubes, P.;Kanwar, S.;Niu, X.;Caboury, J.P. ] / FASEB J.   DOI
38 Nitric oxide release accounts for the biology activity of endothelium derived relaxing factor /
[ Palmer, P.M.J.;Ferrige, A.G.;Monacada, S. ] / Nature   DOI
39 /
[ 朴鎬程;尹泰汝;崔栖瀅;金東圭;具本泓 ] / 東醫內科學
40 허혈,재관류 손상에서 뇌조직 아민 변동 Free Radical과의 관련성 /
[ 이경은;김경환 ] / 大韓神經科學會誌
41 청열도람탕이 뇌혈류개선 및 작용기전에 미치는 영향 /
[ 김희성;정현우 ] / 동의생리병리학회지
42 石菖蒲가 血壓 및 局所腦血流量에미치는 影響 /
[ 鄧鉉雨;康成溶;白承化 ] / 大韓本草學會誌
43 導痰湯이 白鼠의 腦血流改善 및 作用機轉에미치는 影響 /
[ 鄧鉉雨;金義成 ] / 東醫病理學會誌
44 /
[ 楊維傑 ] / 黃帝內經素閭靈樞譯辨
45 /
[ 이천 ] / 醫擧入門
46 眩暈의 針灸治療에 관한 文獻的 考察 /
[ 朴修泳 ] / 大韓針灸學會誌
47 淸暈化痰湯이 局所腦血流量에 미치는 實驗的 硏究 /
[ 김천중;조수인;정현우 ] / 東醫生理病理學會誌
48 淸暈化痰湯加荊芥가 局所腦血流量 및 平均血壓에 미치는 作用機轉 /
[ 閔丙一;任光模;鄭鉉雨 ] / 東醫生理病理學會誌
49 滋陰健脾湯이 拘束 stress흰쥐의 腦 Catecholamine含量 및 體重에 미치는 影響 /
[ 洪大成 ] /
50 滋陰健脾湯이 拘束 스트레스 흰쥐의 胃潰瘍 및 血中 Catecholamine 含量에 미치는 影響 /
[ 姜賢根 ] /
51 자음건비항이 국소뇌혈류량, 평균혈압, 심박동수에 미치는 작용기전 /
[ 정현우;김희성;양기호 ] / 동의생리병리학회지
52 滋陰健脾湯加枳곡<TEX>$\cdot$</TEX>天麻가 腦細胞 및 腦血流變動에 미치는 影響 /
[ 任光模;鄭鉉雨 ] / 東醫生理病理學會誌
53 /
[ 全國韓醫科大學 本草學敎授(拱編) ] / 本草學
54 /
[ Bessen, Mcdermoff ] / Cecil-Loeb textbook of medicine
55 A model of focal ischemic stoke in the rat :reproducible extension cortical infarction /
[ Chen, S.T.;Hsu, C.Y.;Hogan, E.L.;Maricque, H.;Balentlne, J.D. ] / Stroke
56 /
[ 공정현 ] / 萬病回春(卷上)
57 /
[ 許浚 ] / 東醫寶鑑
58 /
[ 上海中醫學院 ] / 中醫內科學
59 어지러움증 환자의 임상 및 검사소견에 관한 연구 /
[ 이향운;박기덕;최경규 ] / 대한신경과학회지
60 /
[ 윤여규 ] / 최신응급의학
61 /
[ 尹用甲 ] / 東醫方劑와 處方解說
62 Endogenous nitric oxide release required for long term synatic depression in the cerebellum /
[ Shibuki, K.;Okada, D. ] / Nature   DOI
63 十二味寬中湯, 凉堯散火湯, 荊防瀉白散이 백서의 혈압 및 국소뇌혈류량에 미치는 영향 /
[ 李基珠;金敬堯 ] / 한국전통의학지
64 /
[ 대한병리학회 ] / 병리학