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Effects of Gamdu-tang Extract in Rat Cardiac Endothelial Cells  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Woo Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Su (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kang Gil Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Gyu (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 352-355 More about this Journal
Abstract
To investigate the protective effect of Gamdu-tang(GDT) and its constituents. Radix Glycyrrhizae(RG) and Semen Glycine(SG) on the damage of cardiac endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen free radical, Neutral Red (NR) and DNA synthesis assay were used. The results were obtained as follows ; Cardiac endothelial cells treated with XO/HX showed the cytotoxicity such as decreases in viability and DNA synthesis. Cardiac endothelial cells pretreated with GDT extracts were not showed the decrease of DNA synthesis by XO/HX, These results show that XO/HX elicits toxic effects in cultured cardiac endothelial cells derived from neonatal rat, and suggest that GDT extract is very effective in the prevention of XO/HX-induced toxicity.
Keywords
Gamdu-tang(甘豆湯); Radix Glycyrrhizae(RG); Semen Glycine(SG); DNA synthesis; xanthine oxidase(XO)/hypoxanthine(HX);
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