Browse > Article

Therapeutic Effects of Ephedra sinica Stapf Herb-Acupuncture on Adjuvant-induced Polyarthritis of Rat  

Lee Han-Chang (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Yeom Mijung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Kim Gun-Ho (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Shim In-Sop (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Choi Kang-Duk (East-West Kidney Center, Kyunghee Medical Center)
Lee Hye-Jung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Hahm Dae-Hyun (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 346-351 More about this Journal
Abstract
The current studies investigated the therapeutic effects of Ephedra sinica Stapf (ES) herb-acupuncture on the inflammatory responses of rat arthritic joint, which was induced by the intradermal injection of heat-killed Mycobacterium tuberculosis emulsified in squalene to the base of the tail. The measurements of body weight and articular index were exploited as the assessment methods addressing arthritic symptoms, and the expression profiles of cytokines such as TNF-α, IL-1β and IL-6 in the rat joint were analyzed using RT-PCR. The articular indexes of arthritic rats were significantly restored after the treatment with ES herb-acupuncture. Although the clinical symptoms of arthritic rats were apparently alleviated by the ES treatments, their body weights were not recovered. It maybe due to the weight-loss and energy enhancement effects of ES extracts. The expression of TNF-α, IL-1β and IL-6 genes, which were highly stimulated in the knee joints of arthritic rats, were restored to the levels of normal rats after the ES treatment. The therapeutic effect of ES herb-acupuncture was not observed in ES-treated, non-acupoint arthritic group as a sham control. The ES herb-acupuncture into an acupoint ST36 was found to be effective in alleviating the arthritic symptoms in adjuvant-induced arthritis rats as regards the body weight, joint appearance and the expression profiles of inflammatory cytokines.
Keywords
Ephedra sinica Stapf(麻黃); herb-acupuncture; arthritis; inflammation; cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis. /
[ Kuiper S;Joosten LA;Bendele AM;Edwards CK 3rd;Arntz OJ;Helsen MM;Van de Loo FA;Van den Berg WB. ] / Cytokine.   DOI
2 Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. /
[ Joosten LA;Lubberts E;Helsen MM;Saxne T;Coenen-de Roo CJ;Heinegard D;van den Berg WB. ] / Arthritis Res.   DOI   ScienceOn
3 Cross-talk between il-1 and i1-6 signaling pathways in rheumatoid arthritis synovial fibroblasts. /
[ Deon D;Ahmed S;Tai K;Scaletta N;Herrero C;Lee IH;Krause A;Ivashkiv LB. ] / J Immunol.   DOI
4 Cytokines in rheumatoid arthritis: trials and tribulations. /
[ Carteron NL. ] / Mol Med Today.   DOI
5 The relative safety of ephedra compared with other herbal products /
[ Bent S;Tiedt TN;Odden MC;Shlipak MG ] / Ann Intern Med
6 Herbal ephedra/ caffeine for weight loss: a 6-month randomized safety and efficacy trial. /
[ Boozer CN;Daly PA;Homel P;Solomon JL;Blanchard D;Nasser JA;Strauss R;Meredith T. ] / Int J Obes Relat Metab Disord.   DOI   ScienceOn
7 /
[ 上海中醫學園 ] / 鍼灸學
8 Expression of cyclooxygenase-l and -2 in rheumatoid arthritis synovium. /
[ Lee YH;Choi SJ;Kim A;Kim CH;Ji JD;Song GG. ] / J Korean Med Sci.   DOI
9 IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. /
[ Woods JM;Katschke KJ;Volin MV;Ruth JH;Woodruff DC;Amin MA;Connors MA;Kurata H;Arai K;Haines GK;Kumar P;Koch AE. ] / J Immunol.   DOI
10 Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. /
[ Kwon YB;Lee JD; Lee HJ;Han HJ;Mar WC;Kang SK;Beitz AJ;Lee JH. ] / Pain.   DOI
11 : Involvement of lL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis. /
[ de Hooge AS;van De Loo FA;Arntz OJ;van Den Berg WB. ] / Am J Pathol.   DOI
12 Adjubant-induced arthritis: IL-<TEX>$\beta$</TEX> , IL-6 and TNF-<TEX>$\alpha$</TEX> are up-regulated in the spinal cord. /
[ Lei Bao;Yu Zhu;Adlan M. Elhassan;Qinyang WU;Baoguo Xiao;Jie Zhu;J. Urban Lindgren. ] / Neuroimmunology
13 Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 14:397-440, 1996. /
[ Feldmann M;Brennan FM;Maini RN. ] / Curr Opin Rheumatol.   DOI
14 /
[ 全國韓醫科大學 鍼灸經穴學校室(編著) ] / 鍼灸學 上, 下.
15 The importance of subchondral bone in osteoarthrosis. /
[ Burr D. B. ] / Curr Opin Rheumatol.   DOI
16 The importance of subchondral bone in osteoarthrosis. /
[ Burr D. B. ] / Curr Opin Rheumatol.   DOI
17 The clinical management of rheumatoid arthritis and osteoarthritis: strategies for improving clinical effectiveness. /
[ Scott D. L.;Shipley M.;Dawson A.;Edwards S.;Symmons D. P.;Woolf A. D. ] / Br J Rheumatol.   DOI
18 /
[ 대한약침학회 ] / 약침요법시술지침서
19 Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. /
[ Leech M;Metz C;Bucala R;Morand EF. ] / Arthritis Rheum.   DOI
20 Anti-neutrophil monoclonal antibody therapy inhibits the development of adjuvant arthritis. /
[ Santos L.L.;Morand E.F.;Hutchinson P.;Boyce N.W.;Holdsworth S.R. ] / Clin Exp Immunol.   DOI
21 /
[ 張仲景 ] / 금궤요략방논
22 /
[ 張馬(合註) ] / 黃帝內經 素問
23 /
[ 朴種國 ] / 鍼灸治療學
24 /
[ 김창민;신민교;안덕균;이경순 ] / 中藥大辭典
25 자침이 류마티시성 관절염에 미치는 효과 /
[ 박경제 ] / 대한동의병리학회지
26 Pathogenesis of joint damage in rheumatoid arthritis: evidence of a dominant role for interleukin-1. /
[ van den Berg WB;Bresnihan B. ] / Baillieres Best Pract Res Clin Rheumatol.   DOI