[KSCI] Korea Science Citation Index Service

Effects of Dojeokseungki-tang on the apoptosis of Leukemia Cell

Park Min Chul (Department of Pathology, College of Oriental Medicine, Woosuk University)
Kwon Jin (Department of Health Administration, Kunjang College)
Jeong Han Sol (Department of Pathology, College of Oriental Medicine, Woosuk University)
Lee Kwang Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 338-345 More about this Journal

Abstract

The purpose of this research was to investigate the anticancer effects of Dojeokseungki-tang(DJSKT) on the various leukemia cell lines. DJSKT treatment suppressed proliferation of cultured-HL60, Jurkat, L1210 cells and increased apoptosis of cultured-L1210, HL60, Molt4, Jurkat cells. DJSKT treatment induced apoptosis of Jurkat cells including the morphologic changes such as the 'ladder pattern' revealed by agarose gel electrophoresis of DNA in a dose-dependent manner. Administration of DJSKT induced apoptosis of transplanted-L1210 cells in vivo, and decreased of mitochondrial transmembrane potential of L 1210 and Jurkat cells in vitro. DJSKT treatment reduced the expression of bcl-2 proteins in Jurkat cells and increased ICE, c-myc, p53 mRNA expression in Molt4 cells. In conclusion, these results suggest that DJSKT might be usefully applied for anti-carcinogenic agent of leukemia.

Keywords

Dojeokseungki-tang(導赤承氣湯); mitochondrial transmenbrane potential; ladder pattern;

Citations & Related Records

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KSCI

Effects of Dojeokseungki-tang on the apoptosis of Leukemia Cell 도적승기탕이 백혈병세포의 Apoptosis에 미치는 효과

Effects of Dojeokseungki-tang on the apoptosis of Leukemia Cell