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Effects of Radix Curcumae Aromaticae Extract in Rat Cardiac Endothelial Cells  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Hyun Gyu (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Choi Ki Bang (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Yong Bok (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.1, 2003 , pp. 71-76 More about this Journal
Abstract
To test the protective effect of Radix Curcumae Aromaticae (RCA) on the damage of cardiac endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen free radical, Neutral Red (NR), thiobarbituric acid reactive substances (TSARS), and DNA synthesis assay were used in the presence of RCA extract. The results of these experiments were obtained as follows ; Cardiac endothelial cells treated with XO/HX showed the cytotoxicity such as decreases in viability and DNA synthesis, a increase in lipid peroxidation. Cardiac endothelial cells pretreated with RCA extract protected the increase of lipid peroxidation by XO/HX. Cardiac endothelial cells pretreated with RCA extract inhibited the decrease of DNA synthesis by XO/HX. These results show that XO/HX elicits toxic effects in cultured cardiac endothelial cells derived from neonatal rat, and suggest that RCA extract is very effective in the prevention of XO/HX-induced toxicity.
Keywords
Radix Curcumae Aromaticae (RCA); xanthine oxidase/hypoxanthine(XO/HX); cardiac endothelial cells; Neutral Red (NR); thiobarbituric acid reactive substances (TSARS); DNA synthesis;
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