[KSCI] Korea Science Citation Index Service

Immuno-Regulatory Effects of Cheongsimondam-tang 청심온담탕의 면역조절 효과

Park Min Chul (Department of Pathology, College of Oriental Medicine, Woosuk University)
Jin Jae Ho (Department of Pathology, College of Oriental Medicine, Woosuk University)
Jung Han Sol (Department of Pathology, College of Oriental Medicine, Woosuk University)
Lee Kwang Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.16, no.6, 2002 , pp. 1223-1229 More about this Journal

Abstract

The purpose of this research was to investigate the effect of Cheongsimondam-tang(CSODT) on the activity of immune cell and anti-carcinogenic effect of mouse leukemia cell. The addition of CSODT(1 ㎍/ml) enhanced the proliferation of cultured-splenocytes and thymocytes. And also administration of CSODT(500 ㎍/kg) accelerated subpopulation of splenic and thymic T lymphocytes especially CD4/sup +/-T/sub H/ cells in BALB/c mice. CSODT treatment decreased cell proliferation and increased apoptotic cell death of cultured-L1210 leukemia cells, and induced apoptosis in addition to decreased mitochondrial transmembrane potential (ΔΨm) of transplanted-L1210 cells in vivo. These results suggest that CSODT have a cellular immuno-regulatory effect and anti-cancer property action.

Keywords

Cheongsimondam-tang(淸心溫膽湯);

Citations & Related Records

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