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Study on the Effect of Benincasae Semen on Cultured Mouse Myocardial Cells Damaged by Adriamycin  

Hong Gi Youn (School of Medicine, Wonkwang University)
Lee Young Mi (School of Medicine, Wonkwang University)
Lee Jung Hun (School of Medicine, Wonkwang University)
Lee Kang Chang (Graduate School of Oriental Medicine, Wonkwang University)
Cho Hae Won (College of Dental Medicine, Wonkwang University)
Han Kyung Su (College of Dental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.6, 2002 , pp. 1207-1210 More about this Journal
Abstract
To examine the cardiotoxic effect of adriamycin on cultured rat myocardial cells, cytotoxicity was measured by MTT assay after cultured myocardial cells were grown with various concentrations of adriamycin(ADA) for 48 hours. The protective effect of Benincasae Semen(BS) on ADR-induced cardiotoxicity was also examined in these cultures. ADR decreased cell viability of cultured rat myocardial cells remarkably in a dose- and time-dependent manners. In protective effect of BS, it was very effective in blocking ADR-induced cytotoxicity. From these results, it is suggested that ADR shows cardioxicity, and the herba extract, as is very effective in preventing ADR-induced cytotoxicity on cultured rat myocardial cells.
Keywords
Adriamycin; Cultured myocardial cell; Benincasae Semen;
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