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Study on Selective Anti-cancer Effects by the Water-extracts of Selaginella Tamariscina in Cancer Cell lines  

Lee Sung Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Ahn Seong Hun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Gwak Gun Sin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kwak Sup (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Jang Cheon (Department of Oriental Medical Prescription Sangi University)
Mun Yean Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Woo Won Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.6, 2002 , pp. 1190-1196 More about this Journal
Abstract
Selaginella Tamariscina is widely used in the traditional oriental herbal medicine for its anti-inflammatory, anti-cancer effects. The effects of aqueous extracts of Selaginella Tamariscina (ST) on the cell viability and induction of apoptotic cell death were investigated in A549, Raw 264.7, C6-glioma. Jurkat and HL-60 cells. The cell viability after treating with extract of Selaginella Tamariscina was quantified by MTT assay method. The results showed that ST decreased the cell viability in HL-60 and Jurkat cells not in A549, Raw 264.7 and C6-glioma cells. And we also observed the chromatin condensation and DNA fragmentation in HL-60 and Jurkat cells. The enzyme activity of caspase-3, tightly regulated by an apoptosis activating complex, were markedly increased in HL-60 cells treated with the ST by dose-dependent manner. In conclusion, our results suggest that the extract of Selaginella Tamariscina may induce the selective apoptotic cell death in HL-60 and Jurkat cells via activation of caspase-3.
Keywords
Selaginella Tamariscina (ST); apoptosis; caspase-3; DNA fragementaion;
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