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Experimental Study on the Anti-allergic Effects of Gamibojungikgi-tang  

Shin Woo jin (Department of Oriental Medicine, Graduate School, Dongeui University)
Kim Dong hyuk (Department of Oriental Medicine, Graduate School, Dongeui University)
Seo Soo Hyun (Department of Oriental Medicine, Graduate School, Dongeui University)
Kam Chul Woo (Department of Oriental Medicine, Graduate School, Dongeui University)
Park Dong il (Department of Oriental Medicine, Graduate School, Dongeui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.6, 2002 , pp. 1157-1163 More about this Journal
Abstract
This experimental research has been done to study the effects of Gmibojungikgi-tang(GBJIKT) on the anti-allergic reaction. We found the several important results from the research which has been performed by two experiments toward immediately type and delayed type in order to study the effects of GBJIKT on hypersensitivity response to mice. The results obtained from our research are as following: The survival rate of one group to which we injected only the compound 48/80 is almost 0% according to its density and timing test. In the other hand, the survival rates of the other group to which we injected both of the compound 48/80 and GBJIKT are 10%, 10%, 20%, 30%, 20%, and 40% according to 0.025, 0.05, 0.1, 0.25 0.5 and 1(mg/g) of compound 48/80. Time dependency test also shows the 0% survival rates in 5 and 10 minutes. GBJIKT revealed the significantly inhibitory effect on Compound 48/80 induced Mast cell degranulation. GBJIKT showed the significantly inhibitory effect in the delayed type hypersensitivity response to picry1 chloride GBJIKT showed the significantly inhibitory effect in the delayed type hypersensitivity response to sheep red blood cell. Our research provides the important evidence that GBJIKT is benificial to the prevention and treatment of allergy related diseases.
Keywords
Gamibojungikgi-tang(加味補中益氣湯); Compound 48/80; anaphylaxis; Picryl chloride(PC); SRBC;
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