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Effect of Bojunglkgi-tang on the Specific Immune Response in BALB/c Mice  

Eun Jae Soon (Department of Pharmacy, Woosuk University)
Chai Hoon (Department of Pharmacy, Woosuk University)
Song Jung Ma (College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 943-947 More about this Journal
Abstract
The purpose of this research was to investigate the effects of Bojunglkgi-tang water extract (BE) on the specific immune response in BALB/c mice. When BE (500mg/kg) was administerd p.o. once a day for 7 days to BALB/c mice, the cell viability of splenocytes was increased and DNA fragmentation of splenocytes was decreased. But, BE did not affect the cell viability and DNA fragmentation of thymocytes. Also, BE increased the population of Thy1/sup +/ cells and TH cells in splenocytes. In addition, BE increased the production of γ -interferon from splenocytes. These results suggest that BE enhances the specific immune response via activation of TH1 cells in splenocytes.
Keywords
Bojunglkgi-tang(補中益氣湯); thymocyte; splenocyte; subpopulation; cytokine;
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