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A Study on the Effects of Sopunghwalhyeoltang-gamibang on the Inhibition of Arthritis Induced by Collagen on the Mouse  

Gwak Jung Mun (Department of Oriental Rehabilitation. College of Oriental Medicine, Daejeon University)
Oh Min Suck (Department of Oriental Rehabilitation. College of Oriental Medicine, Daejeon University)
Park Jong Ho (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
Kim Dong Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 810-817 More about this Journal
Abstract
This study was carried out to know the effects of sopunghwalhyeoltang-gamibang(hereinafter referred to SPHHT) on the inhibition of arthritis induced by collagen on the mouse. Various experimental were performed in vivo (in DBA/1 J mice which are experimental model of arthritis induced by collagen) to analyse the immunomodulatory effects of SPHHT. The results were obtained as follows: 1. The cytotoxicity against mLFC was not measured in all concentration. 2. The arthritis index, incidence, hind paw edema, delayed-type hypersensitivity reaction, spleen weight were reduced in SPHHT treated group. 3. The expression of CD3 ε +/CD4+, CD3 ε +/CD8+ and CD19+ in peripheral blood mononuclear were reduced in SPHHT treated group. 4. The production of pro-inflammatory cytokines such as IL-6 and TNF-α were significantly reduced in SPHHT treated group. 5. The formation of new bones and synivium were stimulated in SPHHT treated group. Comparison of the results for this study showed that Sopung-hwalhyeoltang-gamibang had immunomodulatory effects. So we expect that Sopunghwalhyeoltang-gamibang should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.
Keywords
Sopunghwalhyeoltang-gamibang(疏風活血加味方); arthritis; immunomodulation; cytokine; histopathology;
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