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Effect of Chitosan on the Lipid Metabolism in Treated 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Rats  

Hwang Seock Yeon (Department of Clinical Pathology, Chungbuk National University Hospital)
Yang Jin Bae (College of Oriental Medicine, Taejon University)
Chang Cheoul Soo (Department of Clinical Pathology, Kimcheon Health Siences College)
Kim Tae Up (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Lee Hyung Chul (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 782-787 More about this Journal
Abstract
This study was carried out to investigate the protective effect of chitosan on lipid peroxidation and key lipid parameters in Sprague-Dawley rat (SO rat) accutely exposured to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male SO rats received single intraperitoneal (ip) injection of TCDD (40 j.lg/kg), and were given diet containing 3 or 5% chitosan for 4 weeks from 1 week before TCDD treatment. The gain in body weight was less in group treated with TCDD than in CON group, while that of Ch/H+ TCDD group (5% chitosan diet) increased. The decrease in liver and testis weight caused by TCDD was prevented by high dietary intake of chitosan (5% chitosan). Serum (total cholesterol, triglyceride, HDL-C, and LDL-C) and liver lipid parameters (total lipid, total cholesterol, and triglyceride) were significantly elevated in TCDD-induced rats, but these parameters excluding HDL-C were significantly reduced in high dietary intake of chitosan (5% chitosan). These findings suggest that chitosan is believed to be a possible protective effect against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat.
Keywords
chitosan; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); Sprague-Dawley rat; lipid metabolism;
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