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Immunoreactive Cells of Gastrin and Histamine and the Lymphocytes of Spleen and Thymus in Mice Stomach  

Oh In Kyun (Department of Oriental Physiology, Woosuk University)
Choi Seung Youl (Department of Oriental Pathology, Woosuk University)
Ko Byung Moon (Anatomy and College of Oriental Medicine, Woosuk University)
Lee Kwang Gyu (Department of Oriental Pathology, Woosuk University)
Oh Chan Ho (Division of Biotechnology, Woosuk University)
Lee Chang Hyun (Anatomy and College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 714-719 More about this Journal
Abstract
To examine effects of Whadamcheongwha-tang(WDCWT) extract, the mice investigated the gastrin and histamine secreting cells of the stomach by immunohistochemical method, and the lymphocytes of the spleen and thymus by flow cytometry after the oral administration of WDCWT extract(0.2ml/day) and omeprazole (1mg/day) for 7, 14 and 21 days. The result are as follows; 1. When WDCWT extract was administrated for 7 days, in result, gastrin secreting cells were unchanged. When omeprazole was administrated for 7 and 14 days, gastrin secreting cells were slightly increased than that of normal control group. When WDCWT extract was administrated for 21 days, in result, gastrin secreting cells were significantly increased 1.9 times than that of normal control group. When omeprazole was administrated for 21 days, gastrin secreting cells were increased 1.96 times than that of normal control group. 2. When WDCWT extract and omeprazole were administrated for 7 days, in result, histamine secreting cells were unchanged. When WDCWT extract was administrated for 21 days, in result, histamine secreting cells were significantly increased 1.9 times more than that of normal control group. When omeprazole was administrated for 21 days, in result, histamine secreting cells were increased 2.1 times compared with normal control group. 3. When WDCWT extract administrated for 7, 14 and 21 days, in result, splenic Band T lymphocytes, especially T/sub H/ lymphocytes were significantly increased compared with normal control group, and thymic T/sub H/ lymphocytes were also increased in WDCWT administrated group for 14 days. The results suggest that WDCWT extract inhibit a gastric acid secretion in mice stomach, and is useful in the treatment of the hyperacidity and gastric ulcer.
Keywords
Whadamcheongwha-tang(化痰淸火湯); Gastrin; Histamine; Omeprazole; Stomach;
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