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Study on Study on Antitumor Activity of Kamisamchulsamja-tang  

Kim Seong Eon (Oriental Medical College, Daejon University)
Lee Hyo Jeong (Graduate School of East-West Medical Science, Kyunghee University)
Kim Dong Hee (Oriental Medical College, Daejon University)
Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University)
Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 667-673 More about this Journal
Abstract
The purpose of this study was to investigate the effect of Kamisamchulsamja-tang (KSST) water extract on the antitumor activity. The results were summarized as follows: KSST extract exhibited a weak cytotoxicity against HT1080, A549, SK-OV-3, B16-F10 and SK-MEL-2 cells. KSST extract showed a inhibitoty effect on DNA topoisomerase I from calf thymus in a dose-dependent manner. Also, KSST extract showed antiadhesive effect on HT1080 cells but didn't showed on A549 cells to complex extracellular matrix. In pumonary colonization assay, a number of colonies in the lungs were decreased significantly in KSST treated group as compared with control group. In vitro neovascularization assays, angiogenesis was significantly inhibited in KSST treated group than control group. In CAM assay, KSST extract inhibited angiogenesis significantly at 15㎍/egg concentration as compared with control. From the above results it was concluded that KSST showed antitumor effect through the antimetastatic effect. So it is expected to be clinically helpful on the prevention of metastasis of cancer.
Keywords
Kamisamchulsamja-tang(加味蔘朮三子湯); cytotoXidty; anti-adhesion; CAM assay; TIC %; DNA topoisomerase I;
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1 扶正法在腫瘤治療中的臨床運用 /
[ 陳炳旗 ] / 浙江中醫學院學報
2 /
[ 方藥中 ] / 實用中醫內科學
3 /
[ 大韓病理學會編著 ] / 病理學
4 當歸飮子가섬소가 皮膚癌細胞의 細胞毒性에 미치는 影響 /
[ 崔政和 ] / 大韓外官學會誌
5 癌의 中醫治療 /
[ 여창 ] / 東洋醫學
6 /
[ 柯新橋(外) ] / 癌症效方 240首
7 /
[ 전국의과대학교수 ] / 오늘의 진단 및 치료
8 吳一純敎授治療晩期惡性腫瘤的經驗 /
[ 조건무 ] / 陜西醫學
9 加味四君子湯, 加味地黃湯 및 加味君子地黃湯의 抗腫瘍活性과 放射線 副作用 抑制 效果 /
[ 金東熙 ] / 大田大學校大學院 학위논문
10 /
[ 全國韓醫科大學 本草學敎授(共著) ] / 本草學
11 New colorimetric cytotoxicity assay for anticancer-drug screening. /
[ Skehan, P.;Storeng, R.;Scudiero, D.;Monk, A.;Mc Mahon, J.D.;Vistica, J.;Warren, T.;Kenney, S.;Boyd, M.R. ] / J. Natl. Cancer Inst.,
12 /
[ Liu, L. F.;Cozzarelli, N. R.;Wang, J. C.(Eds.) ] / In DNA Topology and its Biological Effects
13 Inhibition of experimental metastasis by castanospermine in mice : Blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors /
[ Martin J. Humphries.;Kazue Matsumoto;Sandra L. White.;Kenneth Olden ] / Cancer Reserach
14 Assays for angiogenesis /
[ Robert, A;Wanda;A Igor, P. ] / Pharmac.Ther.   ScienceOn
15 新血管形成 기작 硏究를 위한 生體外 모델 시스템 확립 /
[ 김응국(外) ] / ECV 304 內皮細胞株를 利用한 新血管形成 모델 및 염기성 섬유아세포 成長因子의 生産
16 /
[ Hellmann, K.;Carter, S.K. ] / Fundamentals of cancer chemotherapy
17 /
[ 崔昇勳 ] / 東醫腫瘍學
18 惡性腫瘤中西醫結合硏究成就 /
[ 中國中西醫結合硏究會 中國中醫硏究院(編) ] / 中西醫結合雜誌
19 紅花가 人體의 癌細胞柱에 미치는 影響 /
[ 한종현(外) ] / 大韓韓醫學會誌
20 /
[ 왕빙 ] / 抗癌中藥方選
21 /
[ 李岩 ] / 腫瘤臨床備要
22 /
[ Champoux, J. J.;Cozzarelli, N. R.;Wang, J. C.(Eds.) ] / In DNA Topology and its Biological Effects
23 Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin /
[ Y. H. Hsiang; L. F. Liu ] / Cancer Res.
24 Stabilization of type I topoisomerase-DNA covalent complexed by actinomycin D /
[ D. K. Trask;M. T. Muller ] / Proc. Natl. Acad. Sci. USA.   ScienceOn
25 /
[ Higgins, N. P.;Ferro, A. M.;Olivera, B. M.;Cozzarelli, N. R.;Wang, J. C. (Eds.) ] / In DNA Topolgy and its Biological Effects
26 /
[ 李春海(外) ] / 腫瘤生物學硏究進展
27 Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor. /
[ Oikawa, T.;Hasegawa, M.;Shimamura, M.;Ashino-Fuse, H.;Murota, S.I.;Morita, I. ] / Biochem. Biophys. Res. Comm.   ScienceOn
28 Inhibitory effects of antiangiogenic agents on neovascularization. /
[ Tanaka, N. G.;Sakamoto, N.;Tohgo, A.;Nishiyama, Y.;Ogawa, H. ] / Exp. Pathol.
29 Tumor growth and neovascularization: An experimental model using the rabbit cornea. /
[ Gimbrone, M. A. JR.;Cotran, R. A.; Leapman, S. B.;Folkman, J. ] / J. natn. Cancer Inst.
30 Wound healing angiogenesis : indirect stimulation by basic fibroblast growth factor. /
[ Knighton, D. R.;Phillips, G. D.;Fiegel, V. D. ] / J. Trauma
31 The implication of angiogenesis for the biology and therapy of cancer metastasis /
[ Fidker, I. J.;Ellis, L. M. ] / Cell   ScienceOn
32 Tumor angiogenesis : Therapeutic implications /
[ Folkman, J. ] / N Engl J Med.   ScienceOn
33 Angiogenic aqctivity of rat mammary carcinomas induced by 7,12-dimethylbenz[α]anthracene and its inhibition by medroxyprogesteron acetate: possible involvement of antiangiogenic action of medroxyprogesteron acetate in its tumor growth inhibition. /
[ Okawa, T.;Hiragun, A.;Yosida, Y.;Ashino-Fuse, H.;Tominaga, T.;Iwagushi, T. ] / Cancer Lett.