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Angiogenic Inhibition Effects of Several Herbs Supplementing Qi and Blood  

Lee Jin Wha (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Kim Han Young (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Kang Hee (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Yu Young Beob (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Shim Bum Sang (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Choi Seung Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Ahn Kyoo Seok (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 499-506 More about this Journal
Abstract
Two of the essential processes required for metastasis are neoangiogenesis and tumor cell invasion of basement membranes (BM) and extracellular matrix (ECM). Recently, data showed that herbs removing blood stasis has an anti-angiogenic effects. Tonifying vital Qi and eliminating pathogenic factor was a basic modality in Oriental oncology. In this study, we investigated several Qi and Blood tonics for potent angiogenic inhibitors. Methanol extracts of samples inhibited the proliferation of ECV-304 at the concentration of 100 ㎍/㎖. Zizyphi Fructus, Glycyrrhizae Radix, Angelicae Gigantis Radix decreased the gelatinolytic activity of MMP-9 from ECV-3Q4, at the concentration of 100 ㎍/㎖ in gelatin zymography. In in vitro invasion assay, herbs inhibited the invasion activity of ECV-304 by 53% of control (Ginseng Radix), 39% (Zizyphi Fructus), 36% (Angelicae Gigantis Radix), 25% (Glycyrrhizae Radix). Ginseng Radix inhibited the capillary-like tube formation of ECV-304 at the concentration of 160 ㎍/㎖, Angelicae Gigantis Radix and Paeoniae Radix Alba inhibited at the concentration of 320 ㎍/㎖. These results indicated that Ginseng Radix, Glycyrrhizae Radix, and Angelicae Gigantis Radix could be considered as potent angiogenic inhibitiors.
Keywords
Anti-angiogenesis; ginseng radix; glycyrrhlzae radix; angelicae gigantis radix;
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