Browse > Article

Study on Antitumor and Antimetastatic Effect of Kamigedang-tang  

Lee Dong Hoon (Oriental Medical College, Daejon University)
Kim Dong Hee (Oriental Medical College, Daejon University)
Kang In Cheol (Graduate School of East-West Medical Science, Kyunghee University)
Park Young Mi (Department of Biology, Inchon University)
Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University)
Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 472-478 More about this Journal
Abstract
The purpose of this study was to investigate the effect of Kamigedang-tang(KGDT) water extract on the antitumor and anti metastatic activity. The results were summarized as follows: KGDT extracts exhibited a significant cytotoxicity against P388, SK-MEL-2, SK-OV-3, and B16-F10 cell lines and showed significant inhibitoty effect on DNA topoisomerase I from calf thymus. The T/C% was 122.9% in KGDT treated group in S-180 bearing ICR mice. Also, KGDT extracts exhibited efficient affect adhesive effect of A549 cell to complex extracellular matrix. In CAM assay, KGDT extracts inhibited angiogenesis at 15㎍/egg concentration insignificantly as compared with control. These results suggested that KGDT extracts might be usefully applied for prevention and treatement of cancer.
Keywords
Kamigedang-tang(加味抵當湯); cytotoxicity; anti-adhesion; CAM assay; T/C %; DNA topoisomerase I;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin /
[ Y. H. Hsiang;L. F. Liu ] / Cancer Res.
2 /
[ 金聖勳 ] / 東醫病理學
3 /
[ 沈龍燮 ] / 子宮細胞에 대한 穿山甲散 煎湯液과 抗癌劑의 倂用投與 效果
4 /
[ 文宗模 ] / 계지복령환,抵當湯 및 桂枝茯 丸合抵當湯이 endotoxin 으로 誘發된 白鼠의 血栓症에 미치는 影響
5 /
[ 方藥中 ] / 實用中醫內科學
6 /
[ 李尙仁(外) ] / 方劑學
7 /
[ 文濬典;安圭錫;崔昇勳 ] / 東醫病理學
8 /
[ 楊寶仁 ] / 癌症的中藥治療
9 數種 韓藥劑의 抗癌活性 硏究 /
[ 康坼林 ] / 大田大學校 韓醫學硏究所 論文集
10 /
[ 顔德馨 ] / 活血化瘀療法臨床實踐
11 紅花가 人體의 癌細胞柱에 미치는 影響 /
[ 한종현(외) ] / 大韓韓醫學會誌
12 丹蔘의 抗癌效果와 活性物質 分離에 對한 硏究 /
[ 李權益(外) ] / 東醫病理學會誌
13 活血化瘀藥和抗癌藥物對細胞表面的作用 /
[ 傅乃武等 ] / 中華腫瘤雜誌
14 /
[ 吳謙등 ] / 醫宗金鑒
15 /
[ 唐宗海 ] / 血證論(評釋 裴正學)
16 /
[ 張機 ] / 금궤요략
17 抵當湯이 血栓에 미치는 影響 /
[ 林光模 ] / 東醫病理學會誌
18 Stabilization of type I topoisomerase-DNA covalent complexed by actinomycin D /
[ D. K. Trask;M. T. Muller ] / Proc. Natl. Acad. Sci. USA.   ScienceOn
19 /
[ 金東熙 ] / 加味四君子湯, 加味地黃湯 및 加味君子地黃湯의 抗腫瘍活性과 放射線 副作用 抑制 效果
20 /
[ 蔡仁植 ] / 傷寒論譯詮
21 Correlation of screening data generated with a tetrazolium assay (MTT) versus a protein assay (SRB) against a broad panel of human tumor cell lines /
[ Rubinstein, L.V.;Paull, K.D.;Shoemaker, R.H.;Simmon, R.M.;Skehan, P.;Boyd, M.R. ] / Proceedings of the American Association for Cancer Research
22 New colorimetric cytotoxicity assay for anticancer-drug screening /
[ Skehan, P.;Storeng, R.;Scudiero, D.;Monk, A.;Mc Mahon, J.D.;Vistica, J.;Warren, T.;Kenney, S.;Boyd, M.R. ] / J. Natl. Cancer Inst.
23 /
[ Liu, L. F.;Cozzarelli, N. R.;Wang, J. C.(eds.) ] / DNA topology and its biological effects
24 /
[ Hellmann, K.;Carter, S.K. ] / Fundamentals of cancer chemotherapy
25 A simple procedure for the long term cultivation of chicken embrios /
[ Auerbach, R.;Kubai, L.;Knighton, D.;Forkman, J. ] / Devl Biol.   ScienceOn
26 /
[ 姜順熙 ] / 淸泡逐瘀湯 및 蜂毒이 瘀血病態模型에 미치는 影響
27 /
[ 山東中醫學院 ] / 黃帝內經靈樞校釋
28 /
[ 이천 ] / 醫學入門(外科)