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Screening on Monoamine Oxidase B Inhibitor and Antioxidant Activity from the Water Extracts of Medicinal Plants  

Lee Hyung Chul (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Hwang Sang-Gu (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Kim Dae Gun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Ju Sung Min (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Youl Hyung-Keun (Department of Periodontology, College of Dentistry, Wonkwang University)
Kim Won Shin (Biological Science Major Division of Natural Science and Technology College of Natural Science, Wonkwang University)
An Won Gun (Department of Biology College of Natural Sciences. Kyungpook University)
Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 458-463 More about this Journal
Abstract
This present study was designed to screen medicinal plants for the treatment of brain diseases such as Parkinson's disease or Alzheimer's disease. The inhibitory activity of monoamine oxidase B (MAO-B) was investigated in the water extracts of 56 species traditional medicines. Among the tested medicinal plants, E. lathyris, R. palmatum, F. rhynchonphylla, E. caryophyllata, E. pekinensis and H. syriacus were showed the strong inhibitory activity against MAO-B. Therefore, MAO-B inhibitory activity of 6 traditional medicine extracts in the different concentration (2.5, 6.5 and 12.5 ㎍/ml) was determined. The inhibitory effect of MAO-B was detected with dose dependently in 6 traditional plants extracts. E. caryophyllata and R. palmatum were showed the highest inhibitory activity, the MAO-B inhibitory activity at 2.5㎍ of herbal extract being 58% and 52%, respectively. The water extracts of 6 species were tested on antioxidant activity using radical scavenging effects against ABTS/sup +/. The water extracts of R. palmatum, E. caryphyllata, E. pekinensis and H. syriacus were showed strong antioxidant capacity at 20 ㎍ concentration. Among the 56 medicinal plants investigated, the water extracts of R. palmatum and E. caryphyllata were showed significant antioxidant capacity and MAO-B inhibiory activity. Therefore, R. palmatum and E. caryphyllata are expected to ameliorate the clinical symptoms in Parkinson's disease due to significant MAO-B inhibition and radical scavenging effect.
Keywords
Monoamine oxidase B (MAO-B) inhibitor; antioxidant activity; medicinal plant;
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