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Immunoregulatory Action of Comus officinalis Sieb.et Zucc  

Lee Won Bum (Department of Pathology, College of Oriental medicine, Woosuk University)
Jung Han Sol (Department of Pathology, College of Oriental medicine, Woosuk University)
Kwon Jin (Department of Health Administration, Kunjang College)
Oh Chan Ho (Division of Biotechnology, Woosuk University)
Lee Kwang Gyu (Department of Pathology, College of Oriental medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.2, 2002 , pp. 267-271 More about this Journal
Abstract
The purpose of this research was to investigate the immunoregulatory effect, apoptosis of L 1210 leukemia cells of Comus officinalis Sieb.et Zucc. The proliferation of cultured splenocytes and thymocytes were enhanced by the addition of SSY. Splenic, thymic and mesenteric lymph node-T lymphocytes, especially TH cells was significantly increased in SSY-administered (p.o. for 7 days) mice. SSY treatment induced the apoptosis of L1210 mouse leukemia cells. In addition, SSY accelerated the phagocytic activity and nitric oxide production in peritoneal macrophages. These results suggest that SSY have an immuno-regulatory property and anti-cancer effect.
Keywords
Comus officinalis Sieb.et Zucc.; splenocyte; thymocyte; lymph node cell; macrophage;
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