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Inhibitory Effects of Immediate-Type Allergic Reaction of Okbyungpoongsan-Gami by Anal Therapy  

Cho Jeong Yeon (Department of Internal Medicine. College of Oriental Medicine. Wonkwang University)
Moon Gu (Department of Internal Medicine. College of Oriental Medicine. Wonkwang University)
Moon Suk Jae (Department of Internal Medicine. College of Oriental Medicine. Wonkwang University)
Won Jin Hee (Department of Internal Medicine. College of Oriental Medicine. Wonkwang University)
You Kyoung Tae (Department of Internal Medicine. College of Oriental Medicine. Wonkwang University)
Lee Jong Deok (Department of Radiology of Gwangju Wonkwang Hospital)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.2, 2002 , pp. 239-244 More about this Journal
Abstract
Okbyungpoongsan-Gami (OG) has been used for the treatment of excessive sweating with general weakness and allergic rhinitis recently. Anal therapy is another way of taking Oriental medicine. It is an important pathway but not available in common clinical situation. This experiment was performed in order to study the inhibitory effect of immediate-type allergic reaction of OG by anal therapy. In addition, the experiment was practised by 1 H-NMR spectroscopy to examine molecular structure of OG. The results were obtained as follows : OG concentration-dependently inhibited compound 48/80- induced immediate type systemic allergic reaction with concentrations of 0.01-1.0g/kg by anal administration 1 h before injection of compound 48/80. OG also concentration-dependently inhibited compound 48/80- induced ear swelling response with concentrations of 0.01-1g/kg by anal administration 1h before injection of compound 48/80. OG also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody concentration- dependently at concentrations ranging from 0.01 to 1g/kg. When OG was pretreated at concentrations ranging from 0.01 to 1g/ℓ, the histamine release from the rat peritoneal mast cells induced by compound 48/80 was reduced in a concentration-dependent manner. OG (0.1-1g/ℓ) had a significant inhibitory effect on histamine release from IgE-induced activated mast cells. OG is seen to be a biochemical compound certainly by 1 H-NMR spectroscopy According to above results, anal therapy of OG may be beneficial in the treatment of systemic and local immediate-type allergic reactions by inhibition of histamine release from mast cells.
Keywords
Okbyungpoongsan-Gami(玉屛風散加味); Anal Therapy; Immediate-Type Allergic Reaction;
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