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Effects of Bojungchiseup-tang on Renal Expression of Water Channels, Na, K-ATPase and Nitric Oxide Synthase in Rats  

Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim Jang Giun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim Bok Hae (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Cho Dong Ki (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Ryu Do Gon (College of Oriental Medicine, Wonkwang University)
Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.1, 2002 , pp. 72-77 More about this Journal
Abstract
The present study was examined the effects of Bojungchiseup-tang water extract on the renal expression of renal function regulatory proteins including aquaporin 2 (AQP 2), aquaporin 3 (AQP 3), Na, K-ATPase α1 subunit, endothelial nitric oxide synthase (ecNOS), and inducible nitric oxide synthase (iNOS) in rats. The renal expression of AQP 3 was attenuated in rats administered with Bojungchiseup-tang water extract without altered expression of AQP 2, while ecNOS was up-regualted. Oral administration of Bojungchiseup-tang water extract (40 ㎕/100 g) also attenuated the renal expression of Na, K-ATPase α1-subunit and iNOS protein. These results suggest that the diuretic and natriuretic effects of Bojungchiseup-tang maybe causely related with a decreased expression of AQP 3 and increased expression of ecNOS.
Keywords
Bojungchiseup-tang(補中治濕湯); kidney; aquaporin (AQP); Na; K-ATPase; nitric oxide synthase;
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