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Effects of Crataegi Fructus on the Vascular Relaxation and Antioxidative Status  

Son Chang Woo (Department of Physiology, Dongguk University College of Oriental Medicine)
Chae Jong Koo (Department of Physiology, Dongguk University College of Oriental Medicine)
Kim Gil Whon (Department of Physiology, Dongguk University College of Oriental Medicine)
Shin Heung Mook (Department of Physiology, Dongguk University College of Oriental Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.1, 2002 , pp. 67-71 More about this Journal
Abstract
This study investigated the relaxation effects of Crataegi Fructus(CF, Crataegus pinnatifida Bunge) on the contraction evoked by phenylephrine in rabbit carotid artery, and also analyzes antioxidative status in vitro. CF revealed siginificant relaxation on phenylephrine-induced arterial contraction. It's relaxant effect statistically significant in both in the presence of endothelium and absence of endothelium, but statistically exerted more strong relaxation in the presence of endothelium. CF increased in vitro nitric oxide(NO) production in dose-dependent manner. Also, they reduced malondiaidehyde(MDA) concentrations, phosphatidyl choline-liposome(PCOOH) contents, linoleic acid-induced lipid peroxidation and exerted 1,1-diphenyl-2- picryl-hydrazyl(DPPH) radical scavenging effect, in vitro. These results indicate that Crataegi Fructus would be effective in relaxing arterial contraction and it's antioxidative effects may be involved in endothelium-dependent relaxation of artery via vascular protective properites.
Keywords
Crataegi Fructus(CF); arterial contraction; nitric oxide; phosphatidyl choline-liposome; malondialdehyde; DPPH;
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