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Effects of the Fractionation of Sophorae Radix Water Extract on the Langendorff hearts  

Kim Sang Beam (Department of physiology, college of oriental medicine, Wonkwang University)
Kwon Kang Beam (Department of physiology, college of oriental medicine, Wonkwang University)
Park Jun Su (Department of physiology, college of oriental medicine, Wonkwang University)
Park Gwan Ha (Department of Fish pathology, College of Ocean Science & Technology, Kunsan National University)
Ryu Do Gon (Department of physiology, college of oriental medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.1, 2002 , pp. 160-164 More about this Journal
Abstract
The water extract of Sophorae radix was tested for its preventive effects against cardiovascular anaphylaxis elicited in experimental animals. H₂O and ethyl acetate fractionation of Sophorae radix water extract improved anaphylactic cardiac dysfunction in passively sensitized isolated guinea hearts: improvement was noted in the maximal contractile force, post-challenge contractile force, post-challenge coronary flow and creatine kinase change elevation. These results suggest that H₂O and ethyl acute fractionation of Sophorae radix water extract possesses anti-anaphylactic effect in cardiovascular system.
Keywords
Sophorae radix; H₂O and ethyl acetate fractionation; cardiovascular anaphylaxis; anti-anaphylactic effect;
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