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Effect of Ziziphi Jujubae Semen on 5-Fluorouracil Induced cytotoxicity in Cultured Vestibular Neurons  

Son Il Hong (School of Medicine, Wonkang University)
Lee Jung Hun (Institution of Wonkwang Science)
Choi Yu Sun (School of Medicine, Wonkang University)
Lee Jae Kyoo (School of Medicine, Wonkang University)
Kim Hyung Su (School of Medicine, Wonkang University)
Lee Yong Suk (School of Medicine, Wonkang University)
Lee Whan Bong (School of Medicine, Wonkang University)
Choi Ki Wook (School of Medicine, Wonkang University)
Min Bu Ki (School of Medicine, Wonkang University)
Kim Sang Su (School of Medicine, Wonkang University)
Lee Kang Chang (Department of Graduate School of Oriental Medicine, Wonkang University)
Ryu Myeung Hwan (College of Oriental Medicine, Wonkang University)
Song Ho Joon (College of Oriental Medicine, Wonkang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.1, 2002 , pp. 146-149 More about this Journal
Abstract
To evaluate the protective effect of Ziziphi Jujubae Semen(ZJS) on 5-Fluorouracil(5-Fu) in cultured vestibular neurons(VN), neurotoxicity was assessed by XTT assay after VN was exposed to 3-24ug/ml 5-Fu for 48 hours. and also, the neuroprotective effect of ZJS was measured by XTT assay in these cultrures. Cell viability was remarkably decreased dose-dependently, after the treatment with 12ug/ml 5-Fu to cultured VN for 48 hours. In the neuroprotective effect of ZJS on the toxicity induced by 5-Fu, ZJS prevented the neurotoxicity induced by 5-Fu in these cultures. From above the results, it suggests that 5-Fu is toxic in cultured VN and herb extract, ZJS has protective effect over the neurotoxicity induced by 5-Fu.
Keywords
Ziziphi Jujubae Semen (ZJS); vestibular neuron; Neurotoxicity;
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