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Study on Anitmetastatic Effects of Antivascular-first  

Son Chang Kyu (Department of Internal Medicine, college of Oriental Medicine, Daejeon University)
Cho Chong Kwan (Department of Internal Medicine, college of Oriental Medicine, Daejeon University)
Lee Seung ho (Department of Internal Medicine, college of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.1, 2002 , pp. 133-140 More about this Journal
Abstract
To evaluate the anti metastatic effect of Antivascular-first(AntiV-F), we investigated cytotoxic effect on B16-F10 and HMCB. gene expression of MMP-9 and nm23-H1, and survival. After treating with AntiV-F, AntlV-F promoted cytotoxic effect on B16-F10 and HMCB as its density, compared with Control. AntiV-F inhibited gene expression of MMP-9 in the L+14 and HMCB cell line compared with Control. On the other hand AntiV-F increases gene expression of nm23-H1 and survival about 30% compared with Control. These results suggest that AntiV-F has effects on anti-metastasis can be used for treatment of cancer patients and preventing recurrence.
Keywords
antimetastatic effect; Antivascular-first(AntiV-F); MMP-9 and nm23-H1;
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