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http://dx.doi.org/10.14253/acn.2017.19.1.20

Can pursuit eye movements reflect the efficacy of antiepileptic drugs?  

Kim, Si Eun (Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine)
Park, Kang Min (Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine)
Publication Information
Annals of Clinical Neurophysiology / v.19, no.1, 2017 , pp. 20-27 More about this Journal
Abstract
Background: We evaluated whether eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy. Methods: Thirty patients with epilepsy of unknown cause as well as age- and sex-matched normal controls were enrolled in this study. We divided the patients into drug-controlled epilepsy (n = 22) and drug-resistant epilepsy (n = 8) groups according to their seizure controls. We analyzed the differences in the parameters of the eye movements in these two groups compared with normal controls using video-based electro-oculography. In addition, we investigated the differences in the cerebellar volumes of these two groups using whole-brain T1-weighted images. Results: The latency and accuracy of saccade in patients with epilepsy were significantly different from normal controls, but they were not different between patients with drug-controlled epilepsy and drug-resistant epilepsy. However, the gain of pursuit was significantly decreased in patients with drug-resistant epilepsy compared with normal controls (p = 0.0010), whereas it was not different between patients with drug-controlled epilepsy and normal controls (p = 0.9646). In addition, the patients with drug-resistant epilepsy had lower cerebellar volumes than normal controls (p = 0.0052), whereas the cerebellar volumes in patients with drug-controlled epilepsy were not different from normal controls (p = 0.5050). Conclusions: We demonstrated that pursuit eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy, a finding that may be related to cerebellar dysfunction.
Keywords
Epilepsy; Eye movements; Anticonvulsants; Cerebellum;
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