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Leprous Neuropathy Associated with Predominant Proprioceptive Sensory Loss  

Yoon, Tae-Kwan (Pusan National University School of Medicine)
Jo, Hee-Young (Department of Neurology, Pusan National University Yangsan Hospital)
Yuk, Ji-Won (Department of Neurology, Pusan National University Yangsan Hospital)
Shin, Jin-Hong (Department of Neurology, Pusan National University Yangsan Hospital)
Kim, Dae-Seong (Pusan National University School of Medicine)
Publication Information
Annals of Clinical Neurophysiology / v.15, no.1, 2013 , pp. 19-23 More about this Journal
Abstract
Some patients with leprosy may present with atypical features, such as isolated peripheral neuropathy without skin lesions, or marked proprioceptive dysfunction. We report a 56-year-old female who presented with predominant proprioceptive loss without skin lesion, but was finally confirmed as leprous neuropathy by sural nerve biopsy. It is postulated that large myelinated fibers were affected by chronic immunological reactions triggered by inactive bacterial particles, producing a peripheral neuropathy presenting as predominant proprioceptive sensory loss without typical skin lesions.
Keywords
Leprosy; Proprioception; Peripheral neuropathy;
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1 Ooi WW, Srinivasan J. Leprosy and the peripheral nervous system: basic and clinical aspects. Muscle Nerve 2004;30:393-409.   DOI
2 WHO. Global leprosy situation, 2010. Wkly Epidemiol Rec 2010; 85:337.
3 Agrawal A, Pandit L, Dalal M, Shetty JP. Neurological manifestations of Hansen's disease and their management. Clin Neurol Neurosurg 2005;107:445-454.   DOI
4 Skacel M, Antunes SL, Rodrigues MM, Nery JA, Valentim VD, Morais RP, et al. The diagnosis of leprosy among patients with symptoms of peripheral neuropathy without cutaneous lesions: a follow-up study. Arq Neuropsiquiatr 2000;58:800-807.   DOI
5 Pandya SS, Bhakti WS. Severe pan-sensory neuropathy in leprosy. Int J Lepr Other Mycobact Dis 1994;62:24-31.
6 van Brakel WH, Nicholls PG, Das L, Barkataki P, Suneetha SK, Jadhav RS, et al. The INFIR Cohort Study: Investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy, Methods and baseline results of a cohort of multibacillary leprosy patients in north India. Lepr Rev 2005; 76:14-34.
7 Khadilkar SV, Benny R, Kasegaonkar PS. Proprioceptive loss in leprous neuropathy: a study of 19 patients. Neurol India 2008;56:450-455.   DOI
8 Rosenberg NR, Faber WR, Vermeulen M. Unexplained delayed nerve impairment in leprosy after treatment. Lepr Rev 2003;74:357-365.
9 Ha YM. Relapse of Leprosy. Korean Lepr Bull 1994;27:27-29.
10 THELEP: Persisting Mycobacterium leprae among THELEP trial patients in Bamako and Chingleput. Subcommittee on Clinical Trials of the Chemotherapy of Leprosy (THELEP) Scientific Working Group of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. Lepr Rev 1987;58:325-337.