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Periodic Lateralized Epileptiform Discharges Are Not Ictal Phenomenon, and Just Reflect an Acute Brain Damage  

Lee, Sang-Ahm (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
Annals of Clinical Neurophysiology / v.13, no.1, 2011 , pp. 26-30 More about this Journal
Abstract
Although the pathophysiologic mechanism is unknown, there has been long-running debate on whether periodic discharges such as periodic lateralized epileptiform discharges (PLEDs) and generalized periodic epileptiform discharges are an ictal or interictal EEG pattern. The goal of this review is to give evidence that such periodic discharges on EEG are not ictal phenomenon and just represent underlying acute brain damage. This review includes coma with epileptiform EEG pattern and its prognostic and therapeutic implications. Based on previous reports, rather than taking the view PLEDs represent either an underlying ictal process or an electrographic correlate of neuronal injury, it would be more reasonable that PLEDs are considered as a dynamic pathophysiological state in which unstable neurobiological processes create an ictal-interictal continuum.
Keywords
Periodic lateralized epileptiform discharges (PLEDs); Coma; Brain injury; Nonconvulsive status epilepticus; Seizure;
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