Browse > Article
http://dx.doi.org/10.17495/easdl.2015.6.25.3.425

Reducing Effects of Black Rice (Oryza sativa L.) Extract on Body Fat Weight in Ovariectomized Rats  

Lee, Young Min (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Nam, Song Yee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Jang, Hwan Hee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Kim, Jung Bong (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Kim, Haeng Ran (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Lee, Hae-Jeung (Dept. of Food and Nutrition, Eulji University)
Lee, Sung-Joon (Dept. of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University)
Park, Kye Won (Dept. of Food Science and Biotechnology, Sungkyunkwan University)
Lee, Sung Hyen (Functional Food & Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Publication Information
Journal of the East Asian Society of Dietary Life / v.25, no.3, 2015 , pp. 425-431 More about this Journal
Abstract
Estrogen deficiency is associated with increased body weight and fat mass, resulting in obesity-associated complications such as insulin resistance, cardiovascular disease, and type-2 diabetes. The present study was performed to investigate the effect of black rice (Oryza sativa L.) extracts (BRE) on body weight and fat mass in ovariectomized rats. Ovariectomized (or sham-operated) rats were randomly blocked into three groups (n=8~10 per group): sham operated group (S), ovariectomized control group (OVX), and ovariectomized group with BRE 30 mg/kg B.W. (BRE). High fat diet (fat calories 45%) was fed to all experimental rats for 12 weeks. Final body weight, weight gain, and body fat weight showed significant increases in the OVX group, whereas they were reduced by BRE supplementation. Serum TAG, T-chol level, and adipocyte size were not significantly different among the three groups. However, ovariectomy-induced hepatic steatosis was improved in BRE-treated group. Moreover, in the BRE group, serum leptin levels was significantly lower and fecal total lipid concentrations was significantly higher compared to the OVX group. The gathered data suggest that BRE is a potentially useful ingredient to protect against estrogen deficiency-related obesity and its related diseases.
Keywords
Estrogen deficiency; body fat mass; black rice extract; leptin; fecal lipid;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Adam CL, Williams PA, Garden KE, Thomson LM, Ross AW (2015). Dose-dependent effects of a soluble dietary fibre (pectin) on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in rats. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300082/ Accepted January 25, 2015.
2 Andersson T, Soderstrom I, Simonyte K, Olsson T (2010) Estrogen reduces $11{\beta}$-hydroxysteroid dehydrogenase type 1 in liver and visceral, but not subcutaneous, adipose tissue in rats. Obesity 18:470-475.   DOI
3 Bjorndal B, Burri L, Staalesen V, Skorve J, Berge RK (2011) Different adipose depots: Their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic Agents. (http://www.hindawi.com/journals/jobe/2011/490650/ Accepted December 27, 2010)
4 Brighenti F (2007) Dietary fructans and serum triacylglycerols: A meta analysis of randomized controlled trials. J Nutr 137: 2552S-2556S.   DOI
5 Carr MC (2003) The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88: 2404-2411.   DOI
6 Cho MK, Kim MH, Kang MY (2008) Effects of rice embryo and embryo jelly with black rice bran pigment on lipid metabolism and antioxidant enzyme activity in high cholesterol-fed rats. J Korean Soc Appl Biol Chem 51: 200-206.
7 Eisinger K, Liebisch G, Schmitz G, Aslanidis C, Krautbauer S, Buechler C (2014) Lipidomic analysis of serum from high fat diet induced obese mice. Int J Mol Sci 15: 2991-3002.   DOI
8 Frings CS, Dunn RT (1970) A colorimetric method for determination of total serum lipids based on the sulfophospho vanillin reaction. Am J Clin Pathol 53: 89-91.   DOI
9 Hong KH, Kang SA, Kim S, Choue RW (2001) Effects of high fat diet on serum leptin and insulin level and brown adipose tissue UCP 1 expression in rats. Korean J Nutr 34: 865-871.
10 Jang HH, Park MY, Kim HW, Lee YM, Hwang KA, Park JH, Park DS, Kwon O (2012) Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. http://www.nutritionandmetabolism.com/content/9/1/27 Accepted March 30, 2012.
11 Kim JY, Do MH, Lee SS (2006) The effects of a mixture of brown and black rice on lipid profiles and antioxidant status in rats. Ann Nutr Metab 50: 347-353.   DOI
12 Kong S, Choi Y, Lee SM, Lee J (2008) Antioxidant compounds and actioxidant activities of the methanolic extracts from milling fractions of black rice. J Korean Soc Food Sci Nutr 37: 815-819.   DOI
13 Lee SH, Chun HK, Park HJ, Lee YS (2004) Supplementary effect of ${\gamma}$-oryzanol on lipid metabolism in diabetic KK mice. Kor J Nutr 37: 347-351.
14 Lee YM, Jung MH, Lee YS, Song J (2005) Effect of genistein and soy protein on lipids metabolism in ovariectomized rats. Kor J Nutr 38: 267-278.
15 Pandey G, Shihabudeen MS, David HP, Thirumurugan E, Thirumurugan K (2015) Association between hyperleptinemia and oxidative stress in obese diabetic subjects. J Diabetes Metab Disord 14:24.   DOI
16 Medei E, Lima-Leopoldo AP, Pereira-Junior PP, Leopoldo AS, Campos DH, Raimundo JM, Sudo RT, Zapata-Sudo G, Bruder-Nascimento T, Cordellini S, Nascimento JH, Cicogna AC (2010) Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system? Can J Cardiol 26: 542-548.   DOI
17 Meli R, Pacilio M, Raso GM, Esposito E, Coppola A, Nasti A, Di Carlo C, Nappi C, Di Carlo R (2004) Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 145: 3115-3121.   DOI
18 Park YS, Kim M (2012) The effect of Eisenia bicyclis extracts on antioxidant activity and serum lipid level in ovariectomized rats. J Life Science 22: 1407-1414.   DOI
19 Paquette A1, Chapados NA, Bergeron R, Lavoie JM (2009) Fatty acid oxidation is decreased in the liver of ovariectomized rats. Horm Metab Res 41:511-515.   DOI
20 RDA (2011) Food Composition Table. 8th ed. Rural Development Administration. Suwon, Korea. pp 28-29.
21 Rogers NH, Perfield II JW, Strissel KJ, Obin MS, Greenberg AS (2009) Reduced energy expenditure and increased inflammation are early events in the development of ovariectomyinduced obesity. Endocrinology 150: 2161-2168.   DOI
22 Ryu MH, Cha YS (2003) The effects of high-fat or high-sucrose diet on serum lipid profiles, hepatic acyl-CoA syn- thetase, carnitine palmitoyltransferase-I, and the acetyl-CoA carboxylase mRNA levels in rats. J Biochem Mol Biol 36: 312-318.   DOI
23 Son J (2006) Effect of glutinous barley intake on lipid metabolism and antioxidant capacity in middle-aged rats. Ph D Dissertation Ewha Womans University, Seoul. pp 60-61.
24 Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404: 661-667.   DOI
25 Seo SJ, Choi YM, Lee SM, Kong SH, Lee JS (2008) Antioxidant activities and antioxidant compounds of some specialty rices. J Korean Soc Food Sci Nutr 37: 129-135.   DOI
26 Siddiqui NI, Rahman S, Mia AR, Shamsuzzaman AK (2005) Evaluation of hormone replacement therapy. Mymensingh Med J 14: 212-218.
27 Spencer CP, Godsland IF, Stevenson JC (1997) Is there a menopausal metabolic syndrome? Gynecol Endocrinol 11: 341-355.   DOI
28 Sumino H, Ichikawa S, Itoh H, Utsugi T, Ohyama Y, Umeda M, Nakamura T, Kanda T, Mizunuma H, Tomono S, Murakami M, Kurabayashi M (2003) Hormone replacement therapy decreases insulin resistance and lipid metabolism in Japanese postmenopausal women with impaired and normal glucose tolerance. Horm Res 60: 134-142.   DOI
29 Wang JF, Guo YX, Niu JZ, Liu J, Wang LQ, Li PH (2004) Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats. World J Gastroenterol 10: 1967-1970.   DOI
30 Wu T, Qi XM, Liu Y, Guo J, Zhu RY, Chen W, Zheng XD, Yu T (2013) Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice. Food Chem 141: 482-487.   DOI
31 Zawistowski J, Kopec A, Kitts DD (2009) Effects of a black rice extract (Oryza sativa L. indica) on cholesterol levels and plasma lipid parametersin Wistar Kyoto rats. J Funct Foods 1: 50-56.   DOI