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Effects of Aged Deodeok Extract on Serum Lipid Content in Rats Fed a High-Fat Diet  

Park, Sung-Jin (Dept. of Tourism Food Service Cuisine, Hallym College)
Park, Dong-Sik (Funtional Food & Nutrition Division, Rural Development Administration)
Yoon, Won-Byung (Dept. of Food Science and Biotechnology, School of Biotechnology, Kangwon National University)
He, Xinlong (Dept. of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Ahn, Ju-Hee (Dept. of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Journal of the East Asian Society of Dietary Life / v.22, no.1, 2012 , pp. 17-24 More about this Journal
Abstract
This research was performed to investigate the effect of aged Deodeok (Codonopsis lanceolata) water extracts on the levels of lipids in the serum of rats fed a high-fat diet for 10 weeks. Experimental groups were divided into basal diet only (BDG), high fat diet control (HFDCG), high-fat diet and 10% aged deodeok extract powder (HF10S), and high-fat diet and 20% aged deodeok extract powder (HF20S) groups. The levels of hematological variables were not significantly different among the four groups. Compared with the control group's serum total cholesterol level of $339.38{\pm}4.06mg/dL$, the levels of the HF10S and HF20S groups were significantly lowered to $225.38{\pm}5.44$ and $215.02{\pm}4.77mg/dL$, respectively. Compared with the control group's LDL-cholesterol leve of $64.91{\pm}3.67mg/dL$, the LDL-cholesterol levels of the HF10S and HF20S groups were significantly lowered to $54.16{\pm}3.46$ and $46.14{\pm}1.79mg/dL$, respectively. Also, compared to the control group's serum triglyceride level of $103.07{\pm}13.2mg/dL$, the level of the HF20S group was significantly lowered to $48.25{\pm}11.52mg/dL$. These results suggested that dietary supplementation of aged deodeok extract does not have any adverse effect on the hematological variables, while improving the lipid content and reducing hepatic damage of the high-fat fed rats.
Keywords
Aged deodeok; high-fat diet; serum lipid; HDL-cholesterol; total cholesterol;
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