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Relationship between Antioxidant Nutrient Intakes, Blood Oxidative Stress and Inflammatory Markers of Overweight and Obese Adults in Yeongdong Area  

Kim, Mi-Hyun (Dept. of Food and Nutrition, Kangwon National University)
Yeon, Jee-Young (Dept. of Food and Nutrition, Sookmyung Women's University)
Publication Information
Journal of the East Asian Society of Dietary Life / v.21, no.5, 2011 , pp. 637-648 More about this Journal
Abstract
This study was designed to investigate the relationship between the nutrient intakes, antioxidants, and inflammatory markers of overweight and obese adults (46 females and 16 males) in Yeongdong area. The study was conducted through questionnaires, anthropometric checkups, 2-day 24 hr recalls and blood biomarker analyses. Body fat was significantly higher in women compared to men. Diastolic blood pressure (DBP) and systolic blood pressure (SBP) were significantly higher in men compared to women. There were no significant differences in height, weight, body mass index, and waist size among the two groups. The intake of nutrients was significantly higher in men compared to women. Ferric reducing ability plasma (FRAP) was significantly higher in men compared to women. Body fat was positively associated with blood IL-6 and IL-8 levels. DBP was positively associated with FRAP. The intake of protein was negatively associated with IL-6 levels. The intake of carbohydrates was negatively associated with total antioxidant capacity (TAC). Prostaglandin E2 (PGE2) levels were negatively associated with TAC. These results suggest that antioxidant and inflammatory markers may be related to the body fat percentage and dietary intake in overweight and obese adults.
Keywords
Body fat; TAC; IL-6; PGE2; obesity;
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1 Yagi K (1998) Simple procedure for specific assay of lipid hydroperoxides in serum or plasma. Free Radical and Antioxidant Protocols 108: 101-106.
2 Zhao G, Etherton TD, Martin KR, Gillies PJ, West SG, Kris- Etherton PM (2007) Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am J Clin Nutr 85: 385-391.
3 Karakelides H, Sreekumaran NK (2005) Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol 68: 123-148.
4 Kasim-Karakas SE, Tsodikov A, Singh U, Jialal I (2006) Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. Am J Clin Nutr 83: 774-779.
5 Kim JS, Kim HY, Park YK, Kim TS, Kang MH (2003) The effects of green vegetable juice (Angelica keiskei) supplements on plasma lipids and antioxidant status in smokers. Korean J Nutr 36: 933-941.
6 Kim OH, Jung HN, Kim JH (2007) Comparison of food intakes and serum lipid levels in overweight and obese women by body mass index. Korean J Community Nutr 12: 40-49.
7 Kim SA, Sohn CM, Chae DW (2005) Comparison of nutritional status and inflammational markers in DM and nonDM hemodialysis patients. Korean J Community Nutr 10: 693- 699.
8 Kwak HK, Lee MS, Lim SY, Yoon S (2008) Relationship between ferric reducing antioxidant power and metabolic risk factors in Korean women living in Seoul. Korean J Community Nutr 13: 91-99.
9 Lansky D, Brownell KD (1982) Estimates of food quantity and calories : Errors in self-report among obese patients. Am J Clin Nutr 35: 727-732.
10 Lee RD, Nieman DC (1996) Nutritional assessment 2nd ed. Mosby. St Louis.
11 Lerner L, Weiner D, Katz R, Reznick AZ, Pollack S (2009) Increased pro-inflammatory activity and impairment of human monocyte differentiation induced by in vitro exposure to cigarette smoke. J Physiol Pharmacol 60: 81S-86S.
12 Ministry of Health, Welfare and Family Affairs [MOHWFA] & Korea Center for Disease Control and Prevention [KCDCP] (2010) 2009 National Health Statistics- The 4th Korea National Health and Nutrition Examination Survey, the second year(2009), Korea Center for Disease Control and Prevention, Korea.
13 Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P (2000) Glucose challenge stimulates reactive oxygen species(ROS) generation by leucocytes. J Clin Endocrinol Metab 85: 2970-2973.   DOI   ScienceOn
14 Eldar E, Barak V (1996) Increased serum concentration of interleukin- 1$\beta$ in patients with coronary artery disease. Heart 76:24-28.   DOI   ScienceOn
15 Moller P, Viscovich M, Lykkesfeldt J, Loft S, Jensen A, Poulsen HE (2004) Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. Eur J Nutr 43: 267-274.   DOI   ScienceOn
16 Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R (2005) Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111: 1448-54.   DOI   ScienceOn
17 Dreon DM, Frey-Hewitt B, Ellsworth N, Williams PT, Terry RB, Wood PD (1988) Dietary fat : carbohydrate ratio and obesity in middle-aged men. Am J Clin Nutr 47: 995-1000.
18 Forman MR, Lanza E, Yong LC, Holden JM, Graubard BI, Beecher GR, Meltiz M, Brown ED, Smith JC (1993) The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of a carotenoid food-composition database. Am J Clin Nutr 58: 519-524.
19 Giugliano D (2000) Dietary antioxidants for cardiovascular prevention. Nutr Metab Carduovasc Dis 10: 38-44.
20 Gross MD, Snowdon DA (1996) Plasma antioxidant concentration in a population of elderly women: finding from the nun study. Nutr Res 16: 1881-1890.   DOI   ScienceOn
21 Hadley CW, Clinton SK, Schwartz SJ (2003) The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J Nutr 133: 727-732.
22 Heikkilä K, Harris R, Lowe G, Rumley A, Yarnell J, Gallacher J, Ben-Shlomo Y, Ebrahim S, Lawlor DA (2009) Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control 20: 15-26.   DOI   ScienceOn
23 Jung KA, Kim SY, Choi YJ, Woo JI, Chang YK (2001) The nutritional status of antioxidant vitamins in relation to serum MDA level in postmenopausal women. Korean J Nutr 34: 330-337.
24 Benzie IF, Strain JJ (1999) Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299: 15-27.
25 Kallio P, Kolehmainen M, Laaksonen DE, Pulkkinen L, Atalay M, Mykkanen H, Uusitupa M, Poutanen K, Niskanen L (2008) Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr 87: 1497-1503.
26 Kant AK (2003) Interaction of body mass index and attempt to lose weight in a national sample of US adults: association with reported food and nutrient intake, and biomarkers. Eur J Clin Nutr 57: 249-259.   DOI   ScienceOn
27 Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 239: 70-76.   DOI   ScienceOn
28 Bonnie Ky, Anne Burke, Sotirios Tsimikas, Megan L Wolfe, Mahlet G Tadesse, Philippe O Szapary, Joseph L. Witztum, Garret A FitzGerald, Daniel J Rader (2008) The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol 51: 1653-1662.   DOI   ScienceOn
29 Chang HS (2010) Nutrient intakes and blood lipids according to obesity degree by body fat percentage among middleaged women in Gunsan city. Korean J Community Nutr 15: 15-26.
30 Chang HS (2008) A study nutrient intakes and blood lipids of middle aged men living in Jeonbuk province by percentage of body fat. Korean J Community Nutr 13: 334-345.
31 Cho SW, Paek YM, Park YK, Choi TI (2009) The relationship between plasma antioxidant levels and metabolic syndrome risk factors in male workers. Korean J Food Nutr 22: 357-366.
32 Olholm J, Paulsen SK, Cullberg KB, Richelsen B, Pedersen SB (2010) Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. Int J Obes 34: 1546-1553.   DOI
33 Mutlu-Türkoglu U, Ilhan E, Oztezcan S, Kuru A, Aykaç-Toker G, Uysal M (2003) Age-related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects. Clin Biochem 36: 397-400.   DOI   ScienceOn
34 National Institute of Health[NIH] (2003) The seventh report of the Joint National Committee on Prevention, Evaluation and Treatment of High Blood Pressure. U.S. pp 12.
35 Newcomb PA, Carbone PP (1992) The health consequences of smoking. Cancer. Med Clin North Am 76: 305-331.
36 Paolisso G, D'Amore A, Giugliano D, Ceriello A, Varricchio M, D'Onofrio F (1993) Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulindependent diabetic patients. Am J Clin Nutr 57: 650-656.
37 Rokling-Andersen MH, Reseland JE, Veierod MB, Anderssen SA, Jacobs DR, Jr, Urdal P, Jansson JO, Drevon CA (2007) Effects of long-term exercise and diet intervention on plasma adipokine concentrations. Am J Clin Nutr 86: 1293- 1301.
38 Prakash P, Krinsky NI, Russell RM (2000) Retinoids, carotenoids, and human breast cancer cell cultures: a review of differential effects. Nutr Rev 58: 170-176.
39 Rader DJ (2000) Inflammatory markers of coronary risk. N Engl J Med 343: 1179-1182.   DOI   ScienceOn
40 Renehan AG, Roberts DL, Dive C (2008) Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 114: 71-83.   DOI   ScienceOn
41 So WY, Jun TW, Choi DH, Yoon YJ, Kim BM, Seo HY, Eom WS, Kim KL, Park ST, Chang HK, Seo DI, Kim SH, Sung DJ, Lee HJ (2009) The association of life stylerelated factors with hypertension for Korean men. Korean J Sports Medicine 27: 137-143.
42 Talwar D, Ha TK, Scott HR, Cooney J, Fell GS, O'Reilly DS, Lean ME, McMillan DC (1997) Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer. Am J Clin Nutr 66: 1283-1285.
43 Stephensen CB, Gildengorin G (2000) Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 72: 1170-1178.
44 Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C, Jansson JO (2006) Interleukin-1 system gene polymorphisms are associated with fat mass in young men. J Clin Endocrinol Metab 91: 2749-2754.   DOI   ScienceOn
45 Suh YS, Lee IK, Kim DH (2007) Proinflammatory cytokines and insulin resistance in nonobsese women with high body fat and low fat free mass. Diabetes & Metabolism J 31: 136-143.
46 The Korean Nutrition Society[KNS] (2010) Dietary reference intakes for Koreans. p 2-7.
47 Thompson HJ, Heimendinger J, Haegele A, Sedlacek SM, Gillette C, O'Neill C, Wolfe P, Conry C (1999) Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage. Carcinogenesis 20: 2261-2266.   DOI
48 Wild AC, Mulcahy RT (2000) Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses. Free Radic Res 32: 281-301.   DOI   ScienceOn
49 Warstedt K, Furuhjelm C, Duchen K, Fälth-Magnusson K, Fagerås M (2009) The effects of omega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion. Pediatr Res 66: 212-217.   DOI   ScienceOn
50 Watzl B, Kulling SE, Moseneder J, Barth SW, Bub A (2005) A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am J Clin Nutr 82: 1052-1058.