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Correlation between the Expression of Nuclear Factor-$\kappa$B p65 Protein with the Expression of Nuclear Factor-$\kappa$B p50 Protein and the Clinicopathologic Factors in Colorectal Cancer  

Kang, Gi-Chang (Departments of Surgery, College of Medicine, Chung-Ang University)
Kim, Beom-Gyu (Departments of Surgery, College of Medicine, Chung-Ang University)
Park, Jun-Suk (Departments of Surgery, College of Medicine, Chung-Ang University)
Choi, Yu-Sin (Departments of Surgery, College of Medicine, Chung-Ang University)
Cha, Sung-Jae (Departments of Surgery, College of Medicine, Chung-Ang University)
Park, Sung-Jun (Departments of Surgery, College of Medicine, Chung-Ang University)
Chang, In-Taik (Departments of Surgery, College of Medicine, Chung-Ang University)
Park, Sung-Il (Departments of Surgery, College of Medicine, Chung-Ang University)
Lee, Tae-Jin (Departments of Pathology, College of Medicine, Chung-Ang University)
Choi, Young-Cheol (Department of Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine)
Publication Information
Annals of Surgical Treatment and Research / v.75, no.2, 2008 , pp. 84-89 More about this Journal
Abstract
Purpose: Nuclear Factor-κB p65 (NF-κB p65) and nuclear Factor-κB1 p50 (NF-κB p65) have been shown to play roles in cell proliferation, apoptosis, cytokine production and oncogenesis. This study was designed to investigate the expressions of NF-κB p65 and NF-κB p50 proteins in premalignant lesions and colorectal adenocarcinoma. Methods: Paraffin sections of 20 normal mucosa specimens, 20 low grade tubular adenoma specimens, 20 high grade tubular adenoma specimens and 64 adenocarcinoma specimens were analyzed immunohistochemically for the expressions of NF-κB p65 and NF-κB p50 proteins. Results: The expressions of NF-κB p65 and NF-κB p50 proteins were significantly higher in the adenocarcinoma tissue compared with that in the normal mucosa, the low grade tubular adenoma and the high grade tubular adenoma tissues. The frequency of a NF-κB p50 expression was higher in the poorly differentiated histologic grade specimens, in the presence of nodal metastasis and in the high stage specimens. There were significant correlations between the NF-κB p65 and NF-κB p50 proteins. Conclusion: The expressions of NF-κB p65 and NF-κB p50 proteins may play a role in the pathogenesis of colorectal carcinoma. (J Korean Surg Soc 2008;75:84-89)
Keywords
NF-κB p65; NF-κB p50; Colorectal cancer
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