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The Effect of Preoperative Oral Application of Bovine Colostrum on Endotoxemia and TNF-${\alpha}$ in Abdominal Surgery  

Seo, Hyun-Il (Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Jeon, Woo-Kyu (Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Kang, Jin-Ho (Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Lim, Si-Young (Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Lee, Seung-Sei (Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Sohn, Byung-Ho (Departments of General Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Ryu, Chang-Hak (Departments of General Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Shin, Jun-Ho (Departments of General Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Kim, Hung-Dai (Departments of General Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Han, Won-Kon (Departments of General Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Oh, Tae-Yun (Departments of Thoracic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Woo, Hee-Yeon (Departments of Clinical Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Park, Hyo-Soon (Departments of Clinical Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Publication Information
Annals of Surgical Treatment and Research / v.70, no.6, 2006 , pp. 462-469 More about this Journal
Abstract
Purpose: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-${\alpah}$ following the abdominal surgery. Methods: 46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-${\alpah}$ and CRP were also measured. The clinical course was followed and compared in both groups. Results: The colostrum group showed significantly lower level of endotoxin and TNF-${\alpah}$ compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance. Conclusion: Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-${\alpah}$. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum. (J Korean Surg Soc 2006;70:462-469)
Keywords
Bovine colostrums; Endotoxemia; TNF-${\alpha}$; Abdominal surgery;
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Times Cited By KSCI : 1  (Citation Analysis)
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