Effects of Anti-Vascular Endothelial Growth Factor (VEGF) on Pancreatic Islets in Mouse Model of Type 2 Diabetes Mellitus |
Kim, Ji-Won
(Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea)
Ham, Dong-Sik (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) Park, Heon-Seok (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) Ahn, Yu-Bai (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) Song, Ki-Ho (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) Yoon, Kun-Ho (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) Yoo, Ki-Dong (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea) Kim, Myung-Jun (Department of Physiology, The Catholic University, The Catholic University of Korea) Jeong, In-Kyung (Division of Endocrinology & Metabolism, Department of Internal Medicine, Kyung-Hee Uiversity) Ko, Seung-Hyun (Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea) |
1 | Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R: Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 51:3090-4, 2002 DOI PUBMED ScienceOn |
2 | Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM: VEGF -dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290:H560-76, 2006 DOI |
3 | Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fssler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E: The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell 10:397-405, 2006 DOI PUBMED ScienceOn |
4 | Mattsson G: The endothelial cells in islets of langerhans. Ups J Med Sci 110:1-15, 2005 DOI PUBMED |
5 | Lacy PE, Kostianovsky M: Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35–39, 1967 PUBMED |
6 | Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H: Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50:380-9, 2007 DOI |
7 | Pieramici DJ, Rabena MD: Anti-VEGF therapy: comparison of current and future agents. Eye 22:1330-6, 2008 DOI PUBMED ScienceOn |
8 | Nagpal M, Nagpal K, Nagpal PN: A comparative debate on the various anti-vascular endothelial growth factor drugs: pegaptanib sodium (Macugen), ranibizumab (Lucentis) and bevacizumab (Avastin). Indian J Ophthalmol. 55:437-9, 2007 DOI PUBMED |
9 | Tammela T, Enholm B, Alitalo K, Paavonen K: The biology of vascular endothelial growth factors. Cardiovasc Res 65:550-63, 2005 DOI PUBMED ScienceOn |
10 | Christofori G, Naik P, Hanahan D: Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9:1760-70, 1995 DOI PUBMED ScienceOn |
11 | Zilberberg L, Shinkaruk S, Lequin O, Rousseau B, Hagedorn M, Costa F, Caronzolo D, Balke M, Canron X, Convert O, Laïn G, Gionnet K, Goncalvès M, Bayle M, Bello L, Chassaing G, Deleris G, Bikfalvi A: Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor. J Biol Chem 278:35564-73, 2003 DOI PUBMED ScienceOn |
12 | Xie K, Wei D, Shi Q, Huang S: Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev 15:297-324, 2004 DOI ScienceOn |
13 | Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L: VEGF-receptor signal transduction. Trends Biochem Sci 28:488-94, 2003 DOI ScienceOn |
14 | Kakizawa H, Itoh M, Itoh Y, Imamura S, Ishiwata Y, Matsumoto T, Yamamoto K, Kato T, Ono Y, Nagata M, Hayakawa N, Suzuki A, Goto Y, Oda N: The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients. Metabolism 53: 550-5, 2004 DOI ScienceOn |
15 | Lu M, Kuroki M, Amano S, Tolentino M, Keough K, Kim I, Bucala R, Adamis AP: Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest 1:1219-24, 1998 DOI PUBMED ScienceOn |
16 | Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO: Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147:2315-24, 2006 DOI ScienceOn |
17 | Vasir B, Jonas JC, Steil GM, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S, Weir GC: Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation 71:924-35, 2001 DOI PUBMED ScienceOn |
18 | Stagner J, Mokshagundam S, Wyler K, Samols E, Rilo H, Stagner M, Parthasarathy L, Parthasarathy R: Beta-cell sparing in transplanted islets by vascular endothelial growth factor. Transplant Proc 36:1178-80, 2004 DOI PUBMED ScienceOn |
19 | Binetruy-Tournaire R, Demangel C, Malavaud B, Vassy R, Rouyre S, Kraemer M, Plouët J, Derbin C, Perret G, Mazie JC: Identification of a peptide blocking vascular endothelial growth Factor (VEGF) -mediated angiogenesis. EMBO J 19:1525-33, 2000 DOI PUBMED ScienceOn |
20 | Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA: Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13:1070-4, 2000 DOI ScienceOn |
21 | Kuroki M, Voest EE, Amano S, Beerepoot LV, Takashima S, Tolentino M, Kim RY, Rohan RM, Colby KA, Yeo KT, Adamis AP: Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest 98:1667-75, 1996 DOI PUBMED ScienceOn |
22 | de Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH: Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 12:993-1000, 2001 PUBMED |
23 | Konstantinova I, Lammert E: Microvascular development: learning from pancreatic islets. Bioessays 26:1069-75, 2004 DOI PUBMED ScienceOn |
24 | Hammes HP, Lin J, Bretzel RG, Brownlee M, Breier G: Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes 47:401-6, 1998 DOI PUBMED ScienceOn |
25 | Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13:9-22, 1999 |
26 | Linn T, Schneider K, Hammes HP, Preissner KT, Brandhorst H, Morgenstern E, Kiefer F, Bretzel RG: Angiogenic capacity of endothelial cells in islets of Langerhans. FASEB J 17:881-3, 2003 DOI PUBMED |
27 | Ferrara N, Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev 18:4-25, 1997 DOI ScienceOn |
28 | Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, Treutelaar MK, Burant CF: Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 55:2965-73, 2006 DOI ScienceOn |
29 | Simorre-Pinatel V, Guerrin M, Chollet P, Penary M, Clamens S, Malecaze F, Plouet J: Vasculotropin -VEGF stimulates retinal capillary endothelial cells through an autocrine pathway. Invest Ophthalmol Vis Sci 35:3393-400, 1994 PUBMED |
30 | Weibel ER: Stereologic methods. In practical Methods for Biologic Morphometry. Vol. 1, London, Academic Press 101-61, 1978 |
31 | Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC-b inhibitor. Science 272:728-31, 1996 DOI PUBMED ScienceOn |
32 | Zhang N, Richter A, Suriawinata J, Harbaran S, Altomonte J, Cong L, Zhang H, Song K, Meseck M, Bromberg J, Dong H: Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes 53:963-70, 2004 DOI PUBMED ScienceOn |
33 | Byrne AM, Bouchier-Hayes DJ, Harmey JH: Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 9:777-94, 2005 DOI PUBMED ScienceOn |
34 | Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco AP: Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 43:725-30, 1987 DOI |