Palmitic acid induces inflammatory cytokines and regulates tRNA-derived stress-induced RNAs in human trophoblasts |
Changwon Yang
(Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Garam An (Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University) Jisoo Song (Department of Biological Sciences, Sungkyunkwan University) Gwonhwa Song (Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University) Whasun Lim (Department of Biological Sciences, Sungkyunkwan University) |
1 | Abrahams VM. 2011. The role of the Nod-like receptor family in trophoblast innate immune responses. J. Reprod. Immunol. 88:112-117. DOI |
2 | Amine H, Benomar Y, Taouis M. 2021. Palmitic acid promotes resistin-induced insulin resistance and inflammation in SHSY5Y human neuroblastoma. Sci. Rep. 11:5427. (Erratum published 2021, Sci. Rep. 11:12935) |
3 | Bae H, Yang C, Lee JY, Park S, Bazer FW, Song G, Lim W. 2020. Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy. J. Pineal Res. 69:e12670. |
4 | Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM, Hauguel-de Mouzon S. 2008. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 29:274-381. DOI |
5 | Chen X, Scholl TO, Leskiw M, Savaille J, Stein TP. 2010. Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia. Diabetes Care 33:2049-2054. DOI |
6 | Choi J, Yang C, Lim W, Song G, Choi H. 2022. Antioxidant and apoptotic activity of cocoa bean husk extract on prostate cancer cells. Mol. Cell. Toxicol. 18:193-203. DOI |
7 | Colvin BN, Longtine MS, Chen B, Costa ML, Nelson DM. 2017. Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts. Reproduction 153:369-380. DOI |
8 | Eastman AJ, Moore RE, Townsend SD, Gaddy JA, Aronoff DM. 2021. The influence of obesity and associated fatty acids on placental inflammation. Clin. Ther. 43:265-278. DOI |
9 | Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, Hote P, McClain CJ. 2007. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 46:823-830. DOI |
10 | Korbecki J and Bajdak-Rusinek K. 2019. The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms. Inflamm. Res. 68:915-932. DOI |
11 | Lyons SM, Fay MM, Ivanov P. 2018. The role of RNA modifications in the regulation of tRNA cleavage. FEBS Lett. 592: 2828-2844. DOI |
12 | Madan JC, Davis JM, Craig WY, Collins M, Allan W, Quinn R, Dammann O. 2009. Maternal obesity and markers of inflammation in pregnancy. Cytokine 47:61-64. DOI |
13 | Manuel CR, Charron MJ, Ashby CR Jr, Reznik SE. 2018. Saturated and unsaturated fatty acids differentially regulate in vitro and ex vivo placental antioxidant capacity. Am. J. Reprod. Immunol. 80:e12868. |
14 | Pan L, Huang X, Liu ZX, Ye Y, Li R, Zhang J, Wu G, Bai R, Zhuang L, Wei L, Li M, Zheng Y, Su J, Deng J, Deng S, Zeng L, Zhang S, Wu C, Che X, Wang C, Chen R, Lin D, Zheng J. 2021. Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression. J. Clin. Invest. 131:e148130. |
15 | Marques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martinez JA, Marti A. 2015. Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB J. 29:3595-3611. DOI |
16 | Mor G. 2008. Inflammation and pregnancy: the role of toll-like receptors in trophoblast-immune interaction. Ann. N. Y. Acad. Sci. 1127:121-128. DOI |
17 | Natarajan SK, Bruett T, Muthuraj PG, Sahoo PK, Power J, Mott JL, Hanson C, Anderson-Berry A. 2021. Saturated free fatty acids induce placental trophoblast lipoapoptosis. PLoS One 16:e0249907. |
18 | Park H, Song G, Lim W. 2021. Isoprocarb induces acute toxicity in developing zebrafish embryos through vascular malformation. J. Anim. Reprod. Biotechnol. 36:17-24. DOI |
19 | Saikia M, Krokowski D, Guan BJ, Ivanov P, Parisien M, Hu GF, Anderson P, Pan T, Hatzoglou M. 2012. Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J. Biol. Chem. 287:42708-42725. DOI |
20 | Sano M, Shimazaki S, Kaneko Y, Karasawa T, Takahashi M, Ohkuchi A, Takahashi H, Kurosawa A, Torii Y, Iwata H, Kuwayama T, Shirasuna K. 2020. Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice. J. Reprod. Dev. 66:241-248. DOI |
21 | Schenk S, Saberi M, Olefsky JM. 2008. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 118: 2992-3002. DOI |
22 | Yamasaki S, Ivanov P, Hu GF, Anderson P. 2009. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J. Cell Biol. 185:35-42. DOI |
23 | Simko M, Totka A, Vondrova D, Samohyl M, Jurkovicova J, Trnka M, Cibulkova A, Stofko J, Argalasova L. 2019. Maternal body mass index and gestational weight gain and their association with pregnancy complications and perinatal conditions. Int. J. Environ. Res. Public Health 16:1751. |
24 | Su Z, Frost EL, Lammert CR, Przanowska RK, Lukens JR, Dutta A. 2020. tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immuneactivation autism model. RNA Biol. 17:1183-1195. DOI |
25 | Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP. 2011. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12:408-415. DOI |
26 | Yang C, Bae H, Song G, Lim W. 2020. Quercetin affects spermatogenesis-related genes of mouse exposed to high-cholesterol diet. J. Anim. Reprod. Biotechnol. 35:73-85. DOI |
27 | Yang C, Lim W, Bazer FW, Song G. 2017. Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. Mol. Hum. Reprod. 23:755-770. DOI |
28 | Yang C, Lim W, Bazer FW, Song G. 2018. Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells. J. Nutr. Biochem. 54:35-47. DOI |
29 | Yang C, Lim W, Park J, Park S, You S, Song G. 2019. Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells. Mol. Hum. Reprod. 25:755-771. DOI |
30 | Yang C, Park S, Song G, Lim W. 2022. Inhibition of the cleaved half of tRNAGly enhances palmitic acid-induced apoptosis in human trophoblasts. J. Nutr. Biochem. 99:108866. |
31 | Zhong F, Hu Z, Jiang K, Lei B, Wu Z, Yuan G, Luo H, Dong C, Tang B, Zheng C, Yang S, Zeng Y, Guo Z, Yu S, Su H, Zhang G, Qiu X, Tomlinson S, He S. 2019. Complement C3 activation regulates the production of tRNA-derived fragments GlytRFs and promotes alcohol-induced liver injury and steatosis. Cell Res. 29:548-561. DOI |
32 | Yin A, Chen Q, Zhong M, Jia B. 2021. MicroRNA-138 improves LPS-induced trophoblast dysfunction through targeting RELA and NF-κB signaling. Cell Cycle 20:508-521. DOI |
33 | Zhang Y, Ren L, Sun X, Zhang Z, Liu J, Xin Y, Yu J, Jia Y, Sheng J, Hu GF, Zhao R, He B. 2021. Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs. Nat. Commun. 12:6673. |
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